Challenges and opportunities for siRNA-based cancer treatment

Wang, Tao, Shigdar, Sarah, Al Shamaileh, Hadi, Gantier, Michael P., Yin, Wang, Xiang, Dongxi, Wang, Lan, Zhou, Shu-Feng, Hou, Yingchun, Wang, Peng, Zhang, Weihong, Pu, Chunwen and Duan, Wei 2017, Challenges and opportunities for siRNA-based cancer treatment, Cancer letters, vol. 387, pp. 77-83, doi: 10.1016/j.canlet.2016.03.045.

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Title Challenges and opportunities for siRNA-based cancer treatment
Author(s) Wang, Tao
Shigdar, SarahORCID iD for Shigdar, Sarah
Al Shamaileh, Hadi
Gantier, Michael P.
Yin, WangORCID iD for Yin, Wang
Xiang, Dongxi
Wang, Lan
Zhou, Shu-Feng
Hou, Yingchun
Wang, Peng
Zhang, Weihong
Pu, Chunwen
Duan, WeiORCID iD for Duan, Wei
Journal name Cancer letters
Volume number 387
Start page 77
End page 83
Total pages 7
Publisher Elsevier
Place of publication Shannon, Ireland
Publication date 2017-02-28
ISSN 1872-7980
Keyword(s) RNA interference
EPR effect
endosome escape
Summary As one of the life-threatening diseases involving multi-step genetic and epigenetic disorders, cancer has long been a dynamic research area for siRNA-based therapy as half of the current siRNA-based clinical trials are involved in oncology. However, despite consistent enthusiasm in the academic world, siRNA-based cancer treatment still faces obstacles and difficulties in clinical development. In this article, we discuss key challenges facing siRNA-based cancer treatment revealed from recent clinical and preclinical studies, including chemical modification, tumour penetration, endosomal escape, target selection and off-target effects. In addition, opportunities and avenues for translating siRNA technology from bench to oncologic clinics are explored.
Language eng
DOI 10.1016/j.canlet.2016.03.045
Field of Research 1112 Oncology And Carcinogenesis
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier Ireland
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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