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Plasmodium species: master renovators of their host cells

de Koning-Ward, Tania F., Dixon, Matthew W. A., Tilley, Leann and Gilson, Paul R. 2016, Plasmodium species: master renovators of their host cells, Nature reviews microbiology, vol. 14, no. 8, pp. 494-507, doi: 10.1038/nrmicro.2016.79.

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Title Plasmodium species: master renovators of their host cells
Author(s) de Koning-Ward, Tania F.ORCID iD for de Koning-Ward, Tania F. orcid.org/0000-0001-5810-8063
Dixon, Matthew W. A.
Tilley, Leann
Gilson, Paul R.
Journal name Nature reviews microbiology
Volume number 14
Issue number 8
Start page 494
End page 507
Total pages 14
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2016-08
ISSN 1740-1534
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Microbiology
Summary Plasmodium parasites, the causative agents of malaria, have developed elaborate strategies that they use to survive and thrive within different intracellular environments. During the blood stage of infection, the parasite is a master renovator of its erythrocyte host cell, and the changes in cell morphology and function that are induced by the parasite promote survival and contribute to the pathogenesis of severe malaria. In this Review, we discuss how Plasmodium parasites use the protein trafficking motif Plasmodium export element (PEXEL), protease-mediated polypeptide processing, a novel translocon termed the Plasmodium translocon of exported proteins (PTEX) and exomembranous structures to export hundreds of proteins to discrete subcellular locations in the host erythrocytes, which enables the parasite to gain access to vital nutrients and to evade the immune defence mechanisms of the host.
Language eng
DOI 10.1038/nrmicro.2016.79
Field of Research 060599 Microbiology not elsewhere classified
0605 Microbiology
1108 Medical Microbiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Macmillan Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084873

Document type: Journal Article
Collection: Molecular and Medical Research
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