No effect of multivitamin supplementation on central blood pressure in healthy older people: a randomized controlled trial

Harris, Elizabeth, Rowsell, Renee, Pipingas, Andrew and Macpherson, Helen 2016, No effect of multivitamin supplementation on central blood pressure in healthy older people: a randomized controlled trial, Atherosclerosis, vol. 246, pp. 236-242, doi: 10.1016/j.atherosclerosis.2016.01.030.

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Title No effect of multivitamin supplementation on central blood pressure in healthy older people: a randomized controlled trial
Author(s) Harris, Elizabeth
Rowsell, Renee
Pipingas, Andrew
Macpherson, HelenORCID iD for Macpherson, Helen orcid.org/0000-0002-3603-9359
Journal name Atherosclerosis
Volume number 246
Start page 236
End page 242
Total pages 7
Publisher Elsevier
Place of publication Shannon, Ireland
Publication date 2016-03
ISSN 0021-9150
1879-1484
Keyword(s) augmentation index
arterial stiffness
vitamins
multivitamin
blood pressure
Science & Technology
Life Sciences & Biomedicine
Peripheral Vascular Disease
Cardiovascular System & Cardiology
VITAMIN-D SUPPLEMENTATION
REDUCES ARTERIAL STIFFNESS
ENDOTHELIAL FUNCTION
AORTIC PRESSURE
ASCORBIC-ACID
FOLIC-ACID
WAVE-FORM
HUMANS
POPULATION
Summary BACKGROUND AND AIMS: Central blood pressure rises with age, which increases cardiovascular risk. There is some evidence that nutritional supplements may be useful to reduce central blood pressures in older people, but no studies have investigated the effects of multivitamin supplements for this purpose. This randomized, double-blind, placebo-controlled study investigated the effects of 16-weeks supplementation with gender-specific multivitamin and herbal supplements.

METHOD: Participants were healthy individuals, free from heart disease, and included 160 females aged ≥ 50 and 79 males aged 50-65 years. Analyses of co-variance, correcting for baseline cardiovascular assessments, were used to determine the effects of supplementation on central cardiovascular measures including augmentation index, augmentation pressure and pulse pressure. Significance was set at p = 0.016.

RESULTS: No effects of multivitamin supplementation were observed in either males or females (respectively) for central augmentation index (p = 0.841; p = 0.296), central augmentation pressure (p = 0.794; p = 0.442), and central pulse pressure (p = 0.078; p = 0.304). Similarly, there was no treatment effect observed for brachial systolic, diastolic or pulse pressures.

CONCLUSION: Four months multivitamin supplementation does not appear to exert any benefit to measures of central blood pressure in healthy older people.
Language eng
DOI 10.1016/j.atherosclerosis.2016.01.030
Field of Research 111716 Preventive Medicine
1103 Clinical Sciences
1102 Cardiovascular Medicine And Haematology
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084961

Document type: Journal Article
Collections: Faculty of Health
Institute for Physical Activity and Nutrition
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