New insights into CNS requirements for the copper-ATPase, ATP7A. Focus on "Autonomous requirements of the Menkes disease protein in the nervous system".

La Fontaine, Sharon 2015, New insights into CNS requirements for the copper-ATPase, ATP7A. Focus on "Autonomous requirements of the Menkes disease protein in the nervous system"., American journal of physiology: cell physiology, vol. 309, no. 11, pp. C719-C721, doi: 10.1152/ajpcell.00258.2015.

Attached Files
Name Description MIMEType Size Downloads

Title New insights into CNS requirements for the copper-ATPase, ATP7A. Focus on "Autonomous requirements of the Menkes disease protein in the nervous system".
Author(s) La Fontaine, SharonORCID iD for La Fontaine, Sharon orcid.org/0000-0002-9948-074X
Journal name American journal of physiology: cell physiology
Volume number 309
Issue number 11
Start page C719
End page C721
Publisher American Physiological Society
Place of publication Bethesda, Maryland
Publication date 2015-12-01
ISSN 1522-1563
1522-1563
Keyword(s) Adenosine Triphosphatases
Animals
Cation Transport Proteins
Copper
Female
Male
Menkes Kinky Hair Syndrome
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Physiology
MODEL
Summary COPPER IS INDISPENSABLE for development and function of the central nervous system (CNS). This is dramatically illustrated by the severe neuropathological deficits in Menkes disease, an X-linked copper deficiency disorder resulting from mutation of the gene that encodes an essential copper transporting P1B-type ATPase, ATP7A. Since its discovery over two decades ago, the role of ATP7A in copper transport and homeostasis has been inextricably linked to satisfying systemic and CNS requirements for copper. In a recent issue of American Journal of Physiology-Cell Physiology, Hodgkinson et al. (8) describe an important body of work, which for the first time distinguishes the CNS requirement for ATP7A from the CNS requirement for copper.
Language eng
DOI 10.1152/ajpcell.00258.2015
Field of Research 110902 Cellular Nervous System
060199 Biochemistry and Cell Biology not elsewhere classified
060699 Physiology not elsewhere classified
111699 Medical Physiology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C4.1 Letter or note
ERA Research output type C Journal article
Copyright notice ©2015, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084967

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in TR Web of Science
Scopus Citation Count Cited 3 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 28 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Thu, 20 Oct 2016, 09:22:28 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.