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Effects of increasing neuromuscular electrical stimulation current intensity on cortical sensorimotor network activation: a time domain fNIRS study

Muthalib, Makii, Re, Rebecca, Zucchelli, Lucia, Perrey, Stephane, Contini, Davide, Caffini, Matteo, Spinelli, Lorenzo, Kerr, Graham, Quaresima, Valentina, Ferrari, Marco and Torricelli, Alessandro 2015, Effects of increasing neuromuscular electrical stimulation current intensity on cortical sensorimotor network activation: a time domain fNIRS study, PLoS one, vol. 10, no. 7, Article number : e0131951, pp. 1-17, doi: 10.1371/journal.pone.0131951.

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Title Effects of increasing neuromuscular electrical stimulation current intensity on cortical sensorimotor network activation: a time domain fNIRS study
Author(s) Muthalib, Makii
Re, Rebecca
Zucchelli, Lucia
Perrey, Stephane
Contini, Davide
Caffini, Matteo
Spinelli, Lorenzo
Kerr, Graham
Quaresima, Valentina
Ferrari, Marco
Torricelli, Alessandro
Journal name PLoS one
Volume number 10
Issue number 7
Season Article number : e0131951
Start page 1
End page 17
Total pages 17
Publisher PLoS
Place of publication San Francisco, Calif.
Publication date 2015
ISSN 1932-6203
Keyword(s) Adult
Brain Mapping
Electric Stimulation
Forearm
Hemoglobins
Humans
Linear Models
Male
Middle Aged
Motor Cortex
Muscle, Skeletal
Nerve Net
Oxyhemoglobins
Pain Measurement
Prefrontal Cortex
Sensorimotor Cortex
Spectroscopy, Near-Infrared
Summary Neuroimaging studies have shown neuromuscular electrical stimulation (NMES)-evoked movements activate regions of the cortical sensorimotor network, including the primary sensorimotor cortex (SMC), premotor cortex (PMC), supplementary motor area (SMA), and secondary somatosensory area (S2), as well as regions of the prefrontal cortex (PFC) known to be involved in pain processing. The aim of this study, on nine healthy subjects, was to compare the cortical network activation profile and pain ratings during NMES of the right forearm wrist extensor muscles at increasing current intensities up to and slightly over the individual maximal tolerated intensity (MTI), and with reference to voluntary (VOL) wrist extension movements. By exploiting the capability of the multi-channel time domain functional near-infrared spectroscopy technique to relate depth information to the photon time-of-flight, the cortical and superficial oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin concentrations were estimated. The O2Hb and HHb maps obtained using the General Linear Model (NIRS-SPM) analysis method, showed that the VOL and NMES-evoked movements significantly increased activation (i.e., increase in O2Hb and corresponding decrease in HHb) in the cortical layer of the contralateral sensorimotor network (SMC, PMC/SMA, and S2). However, the level and area of contralateral sensorimotor network (including PFC) activation was significantly greater for NMES than VOL. Furthermore, there was greater bilateral sensorimotor network activation with the high NMES current intensities which corresponded with increased pain ratings. In conclusion, our findings suggest that greater bilateral sensorimotor network activation profile with high NMES current intensities could be in part attributable to increased attentional/pain processing and to increased bilateral sensorimotor integration in these cortical regions.
Language eng
DOI 10.1371/journal.pone.0131951
Field of Research 119999 Medical and Health Sciences not elsewhere classified
MD Multidisciplinary
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, PLoS
Persistent URL http://hdl.handle.net/10536/DRO/DU:30084980

Document type: Journal Article
Collection: School of Psychology
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