You are not logged in.

Comparative activities of milk components in reversing chronic colitis

Kanwar, J.R., Kanwar, R.K., Stathopoulos, S., Haggarty, N.W., MacGibbon, A.K.H., Palmano, K.P., Roy, K., Rowan, A. and Krissansen, G.W. 2016, Comparative activities of milk components in reversing chronic colitis, Journal of dairy science, vol. 99, no. 4, pp. 2488-2501, doi: 10.3168/jds.2015-10122.

Attached Files
Name Description MIMEType Size Downloads

Title Comparative activities of milk components in reversing chronic colitis
Author(s) Kanwar, J.R.
Kanwar, R.K.
Stathopoulos, S.
Haggarty, N.W.
MacGibbon, A.K.H.
Palmano, K.P.
Roy, K.
Rowan, A.
Krissansen, G.W.
Journal name Journal of dairy science
Volume number 99
Issue number 4
Start page 2488
End page 2501
Total pages 15
Publisher Elsevier
Place of publication Atlanta, Ga.
Publication date 2016-04
ISSN 1525-3198
Keyword(s) angiogenin
Osteopontin
conjugated linoleic acid
Modulen IBD
iron-saturated bovine lactoferrin (Fe-blf)
Summary Inflammatory bowel disease (IBD) is a poorly understood chronic immune disorder for which there is no medical cure. Milk and colostrum are rich sources of bioactives with immunomodulatory properties. Here we compared the therapeutic effects of oral delivery of bovine milk-derived iron-saturated lactoferrin (Fe-bLF), angiogenin, osteopontin (OPN), colostrum whey protein, Modulen IBD (Nestle Healthsciences, Rhodes, Australia), and cis-9,trans-11 conjugated linoleic acid (CLA)-enriched milk fat in a mouse model of dextran sulfate-induced colitis. The CLA-enriched milk fat significantly increased mouse body weights after 24d of treatment, reduced epithelium damage, and downregulated the expression of proinflammatory cytokines and nitrous oxide. Modulen IBD most effectively decreased the clinical score at d 12, and Modulen IBD and OPN most effectively lowered the inflammatory score. Myeloperoxidase activity that denotes neutrophil infiltration was significantly lower in mice fed Modulen IBD, OPN, angiogenin, and Fe-bLF. A significant decrease in the numbers of T cells, natural killer cells, dendritic cells, and a significant decrease in cytokine expression were observed in mice fed the treatment diets compared with dextran sulfate administered mice. The Fe-bLF, CLA-enriched milk fat, and Modulen IBD inhibited intestinal angiogenesis. In summary, each of the milk components attenuated IBD in mice, but with differing effectiveness against specific disease parameters.
Language eng
DOI 10.3168/jds.2015-10122
Field of Research 0702 Animal Production
0908 Food Sciences
119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, American Dairy Science Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085110

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in TR Web of Science
Scopus Citation Count Cited 2 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 99 Abstract Views, 3 File Downloads  -  Detailed Statistics
Created: Wed, 27 Jul 2016, 14:33:24 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.