Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "T(H)2-type" immunity associated with development of food allergy

Zhang, Yuxia, Collier, Fiona, Naselli, Gaetano, Saffery, Richard, Tang, Mimi LK., Allen, Katrina J., Ponsonby, Anne-Louise, Harrison, Leonard C. and Vuillermin, Peter 2016, Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "T(H)2-type" immunity associated with development of food allergy, Science translational medicine, vol. 8, no. 321, Article number : 321ra8, pp. 1-8, doi: 10.1126/scitranslmed.aad4322.

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Title Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "T(H)2-type" immunity associated with development of food allergy
Author(s) Zhang, Yuxia
Collier, Fiona
Naselli, Gaetano
Saffery, Richard
Tang, Mimi LK.
Allen, Katrina J.
Ponsonby, Anne-Louise
Harrison, Leonard C.
Vuillermin, PeterORCID iD for Vuillermin, Peter orcid.org/0000-0002-6580-0346
Journal name Science translational medicine
Volume number 8
Issue number 321
Season Article number : 321ra8
Start page 1
End page 8
Total pages 8
Publisher American Association for the Advancement of Science
Place of publication Washington, D.C.
Publication date 2016-01-13
ISSN 1946-6234
1946-6242
Keyword(s) BIS Investigator Group
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Medicine, Research & Experimental
Research & Experimental Medicine
Summary Food allergy is a major health burden in early childhood. Infants who develop food allergy display a proinflammatory immune profile in cord blood, but how this is related to interleukin-4 (IL-4)/T helper 2 (T(H)2)-type immunity characteristic of allergy is unknown. In a general population-derived birth cohort, we found that in infants who developed food allergy, cord blood displayed a higher monocyte to CD4(+) T cell ratio and a lower proportion of natural regulatory T cell (nT(reg)) in relation to duration of labor. CD14(+) monocytes of food-allergic infants secreted higher amounts of inflammatory cytokines (IL-1β, IL-6, and tumor necrosis factor-α) in response to lipopolysaccharide. In the presence of the mucosal cytokine transforming growth factor-β, these inflammatory cytokines suppressed IL-2 expression by CD4(+) T cells. In the absence of IL-2, inflammatory cytokines decreased the number of activated nT(reg) and diverted the differentiation of both nT(reg) and naïve CD4(+) T cells toward an IL-4-expressing nonclassical TH2 phenotype. These findings provide a mechanistic explanation for susceptibility to food allergy in infants and suggest anti-inflammatory approaches to its prevention.
Language eng
DOI 10.1126/scitranslmed.aad4322
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, American Association for the Advancement of Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085114

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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