You are not logged in.

Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?

Tissot, Tazzio, Ujvari, Beata, Solary, Eric, Lassus, Patrice, Roche, Benjamin and Thomas, Frederic 2016, Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?, Biochimica et biophysica acta: international journal of biochemistry and biophysics, vol. 1865, no. 2, pp. 147-154, doi: 10.1016/j.bbcan.2016.01.005.

Attached Files
Name Description MIMEType Size Downloads

Title Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?
Author(s) Tissot, Tazzio
Ujvari, Beata
Solary, Eric
Lassus, Patrice
Roche, Benjamin
Thomas, Frederic
Journal name Biochimica et biophysica acta: international journal of biochemistry and biophysics
Volume number 1865
Issue number 2
Start page 147
End page 154
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-04
ISSN 0006-3002
Keyword(s) Cancer
Ecology
Evolution
Mutations
Non-cell-autonomous effects
Summary By definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. Actually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. In addition to cell-autonomous effects generated by the mutations, non-cell-autonomous effects shape the phenotype of a cancer cell. Here, we review the evidence that a network of biological interactions between subclones drives cancer cell adaptation and amplifies intra-tumor heterogeneity. Integrating the role of mutations in tumor ecosystems generates innovative strategies targeting the tumor ecosystem's weaknesses to improve cancer treatment.
Language eng
DOI 10.1016/j.bbcan.2016.01.005
Field of Research 111201 Cancer Cell Biology
060103 Cell Development, Proliferation and Death
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085158

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 4 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Mon, 28 Nov 2016, 14:35:00 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.