Host manipulation by cancer cells: Expectations, facts, and therapeutic implications.

Tissot, Tazzio, Arnal, Audrey, Jacqueline, Camille, Poulin, Robert, Lefèvre, Thierry, Mery, Frederic, Renaud, Francois, Roche, Benjamin, Massol, Francois, Salzet, Michel, Ewald, Paul, Tasiemski, Aurelie, Ujvari, Beata and Thomas, Frederic 2016, Host manipulation by cancer cells: Expectations, facts, and therapeutic implications., BioEssays, vol. 38, no. 3, pp. 276-285, doi: 10.1002/bies.201500163.

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Title Host manipulation by cancer cells: Expectations, facts, and therapeutic implications.
Author(s) Tissot, Tazzio
Arnal, Audrey
Jacqueline, Camille
Poulin, Robert
Lefèvre, Thierry
Mery, Frederic
Renaud, Francois
Roche, Benjamin
Massol, Francois
Salzet, Michel
Ewald, Paul
Tasiemski, Aurelie
Ujvari, BeataORCID iD for Ujvari, Beata
Thomas, Frederic
Journal name BioEssays
Volume number 38
Issue number 3
Start page 276
End page 285
Total pages 10
Publisher Wiley
Place of publication Hoboken, N.J.
Publication date 2016-03
ISSN 1521-1878
Keyword(s) cancer cell
cancer progression
clinical oncology
host manipulation
parasitic ecology
Summary Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can be regarded as cases of host manipulation in the context of cancer development and progression. We elaborate on how acknowledging the applicability of these principles can offer novel therapeutic and preventive strategies. The manipulation of host phenotype by cancer cells is one more reason to adopt a Darwinian approach in cancer research.
Language eng
DOI 10.1002/bies.201500163
Field of Research 060299 Ecology not elsewhere classified
111201 Cancer Cell Biology
111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Wiley
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