Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii).

Ujvari, Beata, Hamede, Rodrigo, Peck, Sarah, Pemberton, David, Jones, Menna, Belov, Katherine and Madsen, Thomas 2016, Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii)., Scientific reports, vol. 6, pp. 1-5, doi: 10.1038/srep25093.

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Title Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii).
Author(s) Ujvari, Beata
Hamede, Rodrigo
Peck, Sarah
Pemberton, David
Jones, Menna
Belov, Katherine
Madsen, Thomas
Journal name Scientific reports
Volume number 6
Start page 1
End page 5
Total pages 5
Publisher Nature Publishing Group
Place of publication London, Eng
Publication date 2016
ISSN 2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Facial tumor disease
Natural antibodies
Tasmanian tiger
Summary Immunoglobulins such as IgG and IgM have been shown to induce anti-tumour cytotoxic activity. In the present study we therefore explore total serum IgG and IgM expression dynamics in 23 known-aged Tasmanian devils (Sarcophilus harrisii) of which 9 where affected by Devil Facial Tumour Disease (DFTD). DFTD is clonally transmissible cancer that has caused massive declines in devil numbers. Our analyses revealed that IgM and IgG expression levels as well as IgM/IgG ratios decreased with increasing devil age. Neither age, sex, IgM nor IgG expression levels affected devil DFTD status in our analyses. However, devils with increased IgM relative to IgG expression levels had significantly lower DFTD prevalence. Our results therefore suggest that IgM/IgG ratios may play an important role in determining devil susceptibility to DFTD. We consequently propose that our findings warrant further studies to elucidate the underpinning(s) of devil IgM/IgG ratios and DFTD status.
Language eng
DOI 10.1038/srep25093
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
060806 Animal Physiological Ecology
110709 Tumour Immunology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Nature Publishing Group
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