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Understanding the role of maternal diet on kidney development; an opportunity to improve cardiovascular and renal health for future generations

Wood-Bradley, Ryan James, Barrand, Sanna, Giot, Anais and Armitage, James Andrew 2015, Understanding the role of maternal diet on kidney development; an opportunity to improve cardiovascular and renal health for future generations, Nutrients, vol. 7, no. 3, pp. 1881-1905, doi: 10.3390/nu7031881.

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Title Understanding the role of maternal diet on kidney development; an opportunity to improve cardiovascular and renal health for future generations
Author(s) Wood-Bradley, Ryan James
Barrand, Sanna
Giot, Anais
Armitage, James Andrew
Journal name Nutrients
Volume number 7
Issue number 3
Start page 1881
End page 1905
Total pages 25
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2015-03-12
ISSN 2072-6643
Keyword(s) Blood Pressure
Cardiovascular Diseases
Diet
Dietary Proteins
Female
Humans
Kidney
Kidney Diseases
Malnutrition
Organogenesis
Pregnancy
Prenatal Exposure Delayed Effects
Prenatal Nutritional Physiological Phenomena
developmental programming
kidney development
maternal diet
Summary The leading causes of mortality and morbidity worldwide are cardiovascular disease (high blood pressure, high cholesterol and renal disease), cancer and diabetes. It is increasingly obvious that the development of these diseases encompasses complex interactions between adult lifestyle and genetic predisposition. Maternal malnutrition can influence the fetal and early life environment and pose a risk factor for the future development of adult diseases, most likely due to impaired organogenesis in the developing offspring. This then predisposes these offspring to cardiovascular disease and renal dysfunction in adulthood. Studies in experimental animals have further illustrated the significant impact maternal diet has on offspring health. Many studies report changes in kidney structure (a reduction in the number of nephrons in the kidney) in offspring of protein-deprived dams. Although the early studies suggested that increased blood pressure was also present in offspring of protein-restricted dams, this is not a universal finding and requires clarification. Importantly, to date, the literature offers little to no understanding of when in development these changes in kidney development occur, nor are the cellular and molecular mechanisms that drive these changes well characterised. Moreover, the mechanisms linking maternal nutrition and a suboptimal renal phenotype in offspring are yet to be discerned-one potential mechanism involves epigenetics. This review will focus on recent information on potential mechanisms by which maternal nutrition   (focusing on malnutrition due to protein restriction, micronutrient restriction and excessive fat intake) influences kidney development and thereby function in later life.
Language eng
DOI 10.3390/nu7031881
Field of Research 1111 Nutrition And Dietetics
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085232

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.