Effect of polymer microstructure on the docetaxel release and stability of polyurethane formulation

Shaikh, Mohsin, Choudhury, Namita Roy, Knott, Robert, Kanwar, Jagat Rakesh and Garg, Sanjay 2016, Effect of polymer microstructure on the docetaxel release and stability of polyurethane formulation, European journal of pharmaceutics and biopharmaceutics, vol. 101, pp. 82-89, doi: 10.1016/j.ejpb.2016.01.015.

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Title Effect of polymer microstructure on the docetaxel release and stability of polyurethane formulation
Author(s) Shaikh, Mohsin
Choudhury, Namita Roy
Knott, Robert
Kanwar, Jagat RakeshORCID iD for Kanwar, Jagat Rakesh orcid.org/0000-0003-3728-9568
Garg, Sanjay
Journal name European journal of pharmaceutics and biopharmaceutics
Volume number 101
Start page 82
End page 89
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-04
ISSN 0939-6411
1873-3441
Keyword(s) polyurethane
docetaxel
small-angle X-ray diffraction
stability
polymer microstructure
drug release
Summary PurSil®AL20 (PUS), a copolymer of 4,4'-dicyclohexylmethane diisocyanate (HMDI), 1,4-butane diol (BD), poly-tetramethylene oxide (PTMO) and poly-dimethyl siloxane (PDMS) was investigated for stability as a vehicle for Docetaxel (DTX) delivery through oesophageal drug eluting stent (DES). On exposure to stability test conditions, it was found that DTX release rate declined at 4 and 40 °C. In order to divulge reasons underlying this, changes in DTX solid state as well as PUS microstructure were followed. It was found that re-crystallization of DTX in PDMS rich regions was reducing the drug release at both 4 °C and 40 °C samples. So far microstructural features have not been correlated with stability and drug release, and in this study we found that at 40 °C increase in microstructural domain sizes and the inter-domain distances (from ∼85 Å to 129 Å) were responsible for hindering the DTX release in addition to DTX re-crystallization.
Language eng
DOI 10.1016/j.ejpb.2016.01.015
Field of Research 119999 Medical and Health Sciences not elsewhere classified
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085321

Document type: Journal Article
Collection: School of Medicine
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