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Effect of personalized nutrition on health-related behaviour change: evidence from the Food4me European randomized controlled trial

Celis-Morales, Carlos, Livingstone, Katherine M., Marsaux, Cyril F. M., Macready, Anna L., Fallaize, Rosalind, O'Donovan, Clare B., Woolhead, Clara, Forster, Hannah, Walsh, Marianne C., Navas-Carretero, Santiago, San-Cristobal, Rodrigo, Tsirigoti, Lydia, Lambrinou, Christina P., Mavrogianni, Christina, Moschonis, George, Kolossa, Silvia, Hallmann, Jacqueline, Godlewska, Magdalena, Surwiłło, Agnieszka, Traczyk, Iwona, Drevon, Christian A., Bouwman, Jildau, van Ommen, Ben, Grimaldi, Keith, Parnell, Laurence, Matthews, John N. S., Manios, Yannis, Daniel, Hannelore, Martinez, J. Alfredo, Lovegrove, Julie A., Gibney, Eileen R., Brennan, Lorraine, Saris, Wim H. M., Gibney, Mike and Mathers, John C. 2016, Effect of personalized nutrition on health-related behaviour change: evidence from the Food4me European randomized controlled trial, International journal of epidemiology, In Press, pp. 1-11, doi: 10.1093/ije/dyw186.

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Title Effect of personalized nutrition on health-related behaviour change: evidence from the Food4me European randomized controlled trial
Author(s) Celis-Morales, Carlos
Livingstone, Katherine M.ORCID iD for Livingstone, Katherine M. orcid.org/0000-0002-9682-7541
Marsaux, Cyril F. M.
Macready, Anna L.
Fallaize, Rosalind
O'Donovan, Clare B.
Woolhead, Clara
Forster, Hannah
Walsh, Marianne C.
Navas-Carretero, Santiago
San-Cristobal, Rodrigo
Tsirigoti, Lydia
Lambrinou, Christina P.
Mavrogianni, Christina
Moschonis, George
Kolossa, Silvia
Hallmann, Jacqueline
Godlewska, Magdalena
Surwiłło, Agnieszka
Traczyk, Iwona
Drevon, Christian A.
Bouwman, Jildau
van Ommen, Ben
Grimaldi, Keith
Parnell, Laurence
Matthews, John N. S.
Manios, Yannis
Daniel, Hannelore
Martinez, J. Alfredo
Lovegrove, Julie A.
Gibney, Eileen R.
Brennan, Lorraine
Saris, Wim H. M.
Gibney, Mike
Mathers, John C.
Journal name International journal of epidemiology
Season In Press
Start page 1
End page 11
Total pages 11
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2016-08-14
ISSN 1464-3685
Keyword(s) personalized nutrition
diet
genotype
internet-based
metabolic health
obesity
phenotype
randomized controlled trial
Food4Me Study
Summary BACKGROUND: Optimal nutritional choices are linked with better health, but many current interventions to improve diet have limited effect. We tested the hypothesis that providing personalized nutrition (PN) advice based on information on individual diet and lifestyle, phenotype and/or genotype would promote larger, more appropriate, and sustained changes in dietary behaviour. METHODS: Adults from seven European countries were recruited to an internet-delivered intervention (Food4Me) and randomized to: (i) conventional dietary advice (control) or to PN advice based on: (ii) individual baseline diet; (iii) individual baseline diet plus phenotype (anthropometry and blood biomarkers); or (iv) individual baseline diet plus phenotype plus genotype (five diet-responsive genetic variants). Outcomes were dietary intake, anthropometry and blood biomarkers measured at baseline and after 3 and 6 months' intervention. RESULTS: At baseline, mean age of participants was 39.8 years (range 18-79), 59% of participants were female and mean body mass index (BMI) was 25.5 kg/m(2) From the enrolled participants, 1269 completed the study. Following a 6-month intervention, participants randomized to PN consumed less red meat [-5.48 g, (95% confidence interval:-10.8,-0.09), P = 0.046], salt [-0.65 g, (-1.1,-0.25), P = 0.002] and saturated fat [-1.14 % of energy, (-1.6,-0.67), P < 0.0001], increased folate [29.6 µg, (0.21,59.0), P = 0.048] intake and had higher Healthy Eating Index scores [1.27, (0.30, 2.25), P = 0.010) than those randomized to the control arm. There was no evidence that including phenotypic and phenotypic plus genotypic information enhanced the effectiveness of the PN advice. CONCLUSIONS: Among European adults, PN advice via internet-delivered intervention produced larger and more appropriate changes in dietary behaviour than a conventional approach.
Language eng
DOI 10.1093/ije/dyw186
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
0104 Statistics
1117 Public Health And Health Services
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085467

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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