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The effect of the apolipoprotein E genotype on response to personalized dietary advice intervention: findings from the Food4Me randomized controlled trial

Fallaize, Rosalind, Celis-Morales, Carlos, Macready, Anna L., Marsaux, Cyril F. M., Forster, Hannah, O'Donovan, Clare, Woolhead, Clara, San-Cristobal, Rodrigo, Kolossa, Silvia, Hallmann, Jacqueline, Mavrogianni, Christina, Surwillo, Agnieszka, Livingstone, Katherine M., Moschonis, George, Navas-Carretero, Santiago, Walsh, Marianne C., Gibney, Eileen, Brennan, Lorraine, Bouwman, Jildau, Grimaldi, Keith, Manios, Yannis, Traczyk, Iwona, Drevon, Christian A., Martinez, J. Alfredo, Daniel, Hannelore, Saris, Wim H. M., Gibney, Michael J., Mathers, John C. and Lovegrove, Julie A. 2016, The effect of the apolipoprotein E genotype on response to personalized dietary advice intervention: findings from the Food4Me randomized controlled trial, American journal of clinical nutrition, vol. 104, no. 3, pp. 827-836, doi: 10.3945/ajcn.116.135012.

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Title The effect of the apolipoprotein E genotype on response to personalized dietary advice intervention: findings from the Food4Me randomized controlled trial
Author(s) Fallaize, Rosalind
Celis-Morales, Carlos
Macready, Anna L.
Marsaux, Cyril F. M.
Forster, Hannah
O'Donovan, Clare
Woolhead, Clara
San-Cristobal, Rodrigo
Kolossa, Silvia
Hallmann, Jacqueline
Mavrogianni, Christina
Surwillo, Agnieszka
Livingstone, Katherine M.ORCID iD for Livingstone, Katherine M. orcid.org/0000-0002-9682-7541
Moschonis, George
Navas-Carretero, Santiago
Walsh, Marianne C.
Gibney, Eileen
Brennan, Lorraine
Bouwman, Jildau
Grimaldi, Keith
Manios, Yannis
Traczyk, Iwona
Drevon, Christian A.
Martinez, J. Alfredo
Daniel, Hannelore
Saris, Wim H. M.
Gibney, Michael J.
Mathers, John C.
Lovegrove, Julie A.
Journal name American journal of clinical nutrition
Volume number 104
Issue number 3
Start page 827
End page 836
Total pages 10
Publisher American Society for Nutrition
Place of publication Rockville, Md.
Publication date 2016-08-10
ISSN 0002-9165
1938-3207
Keyword(s) APOE
Food4Me
dietary fat
nutrigenomics
personalized nutrition
Food4Me Study
Summary BACKGROUND: The apolipoprotein E (APOE) risk allele (ɛ4) is associated with higher total cholesterol (TC), amplified response to saturated fatty acid (SFA) reduction, and increased cardiovascular disease. Although knowledge of gene risk may enhance dietary change, it is unclear whether ɛ4 carriers would benefit from gene-based personalized nutrition (PN). OBJECTIVES: The aims of this study were to 1) investigate interactions between APOE genotype and habitual dietary fat intake and modulations of fat intake on metabolic outcomes; 2) determine whether gene-based PN results in greater dietary change than do standard dietary advice (level 0) and nongene-based PN (levels 1-2); and 3) assess the impact of knowledge of APOE risk (risk: E4+, nonrisk: E4-) on dietary change after gene-based PN (level 3). DESIGN: Individuals (n = 1466) recruited into the Food4Me pan-European PN dietary intervention study were randomly assigned to 4 treatment arms and genotyped for APOE (rs429358 and rs7412). Diet and dried blood spot TC and ω-3 (n-3) index were determined at baseline and after a 6-mo intervention. Data were analyzed with the use of adjusted general linear models. RESULTS: Significantly higher TC concentrations were observed in E4+ participants than in E4- (P < 0.05). Although there were no significant differences in APOE response to gene-based PN (E4+ compared with E4-), both groups had a greater reduction in SFA (percentage of total energy) intake than at level 0 (mean ± SD: E4+, -0.72% ± 0.35% compared with -1.95% ± 0.45%, P = 0.035; E4-, -0.31% ± 0.20% compared with -1.68% ± 0.35%, P = 0.029). Gene-based PN was associated with a smaller reduction in SFA intake than in nongene-based PN (level 2) for E4- participants (-1.68% ± 0.35% compared with -2.56% ± 0.27%, P = 0.025). CONCLUSIONS: The APOE ɛ4 allele was associated with higher TC. Although gene-based PN targeted to APOE was more effective in reducing SFA intake than standard dietary advice, there was no difference between APOE "risk" and "nonrisk" groups. Furthermore, disclosure of APOE nonrisk may have weakened dietary response to PN. This trial was registered at clinicaltrials.gov as NCT01530139.
Language eng
DOI 10.3945/ajcn.116.135012
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, American Society for Nutrition
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085470

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.