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Antidepressant mechanisms of deep brain stimulation for treatment resistant depression

Kim, Yesul 2015, Antidepressant mechanisms of deep brain stimulation for treatment resistant depression, Ph.D. thesis, School of Psychology, Deakin University.

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Title Antidepressant mechanisms of deep brain stimulation for treatment resistant depression
Author Kim, Yesul
Institution Deakin University
School School of Psychology
Faculty Faculty of Health
Degree type Research doctorate
Degree name Ph.D.
Thesis advisor Byrne, Linda
Tye, Susannah
Date submitted 2015
Keyword(s) deep brain stimulation (DBS)
treatment resistant depression (TRD)
antidepressants
Summary Deep brain stimulation to clinically relevant brain targets all produced therapeutic responses in an animal model of antidepressant resistance. Such effects were achieved by modulating cellular stress, impaired synaptic plasticity, dysregulated dopamine transmission and energy metabolism. The implication of these findings underscore the need for using appropriate animal models to gain valuable insight on the neurobiological state of the organism in health and disease.
Language eng
Field of Research 110319 Psychiatry (incl Psychotherapy)
110903 Central Nervous System
Socio Economic Objective 920111 Nervous System and Disorders
Description of original 303 pages : illustrations, tables, figures, appendices
Copyright notice ┬ęThe Author. All Rights Reserved
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085500

Document type: Thesis
Collections: Higher degree theses (full text)
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.