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Mitochondrial dysfunction in bipolar disorder: evidence, pathophysiology and translational implications

Scaini, Giselli, Rezin, Gislaine T., Carvalho, Andre F., Streck, Emilio L., Berk, Michael and Quevedo, Joao 2016, Mitochondrial dysfunction in bipolar disorder: evidence, pathophysiology and translational implications, Neuroscience & biobehavioral reviews, vol. 68, pp. 694-713, doi: 10.1016/j.neubiorev.2016.06.040.

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Title Mitochondrial dysfunction in bipolar disorder: evidence, pathophysiology and translational implications
Author(s) Scaini, Giselli
Rezin, Gislaine T.
Carvalho, Andre F.
Streck, Emilio L.
Berk, Michael
Quevedo, Joao
Journal name Neuroscience & biobehavioral reviews
Volume number 68
Start page 694
End page 713
Total pages 20
Publisher Elsevier
Place of publication London, Eng.
Publication date 2016-09
ISSN 1873-7528
Keyword(s) mitochondria
bipolar disorder
mania
depression
mitochondrial dysfunction
oxidative stress
inflammation
apoptosis
neurogenesis
Summary Bipolar disorder (BD) is a chronic psychiatric illness characterized by severe and biphasic changes in mood. Several pathophysiological mechanisms have been hypothesized to underpin the neurobiology of BD, including the presence of mitochondrial dysfunction. A confluence of evidence points to an underlying dysfunction of mitochondria, including decreases in mitochondrial respiration, high-energy phosphates and pH; changes in mitochondrial morphology; increases in mitochondrial DNA polymorphisms; and downregulation of nuclear mRNA molecules and proteins involved in mitochondrial respiration. Mitochondria play a pivotal role in neuronal cell survival or death as regulators of both energy metabolism and cell survival and death pathways. Thus, in this review, we discuss the genetic and physiological components of mitochondria and the evidence for mitochondrial abnormalities in BD. The final part of this review discusses mitochondria as a potential target of therapeutic interventions in BD.
Language eng
DOI 10.1016/j.neubiorev.2016.06.040
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085594

Document type: Journal Article
Collection: School of Medicine
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