Multimodal iron oxide (Fe₃O₄)-saturated lactoferrin nanocapsules as nanotheranostics for real-time imaging and breast cancer therapy of claudin-low, triple-negative (ER-/PR-/HER2-)

Kanwar, Jagat R., Kamalapuram, Sishir K., Krishnakumar, Subramanian and Kanwar, Rupinder K. 2016, Multimodal iron oxide (Fe₃O₄)-saturated lactoferrin nanocapsules as nanotheranostics for real-time imaging and breast cancer therapy of claudin-low, triple-negative (ER-/PR-/HER2-), Nanomedicine, vol. 11, no. 3, pp. 249-268, doi: 10.2217/nnm.15.199.

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Title Multimodal iron oxide (Fe₃O₄)-saturated lactoferrin nanocapsules as nanotheranostics for real-time imaging and breast cancer therapy of claudin-low, triple-negative (ER-/PR-/HER2-)
Author(s) Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R. orcid.org/0000-0003-3728-9568
Kamalapuram, Sishir K.
Krishnakumar, Subramanian
Kanwar, Rupinder K.
Journal name Nanomedicine
Volume number 11
Issue number 3
Start page 249
End page 268
Total pages 20
Publisher Future Medicine
Place of publication London, Eng.
Publication date 2016-02
ISSN 1748-6963
Keyword(s) apoptosis
bovine lactoferrin
iron metabolism
multimodal imaging
nanotheranostic
Summary AIM: To unravel the multimodal nanotheranostic ability of Fe3O4-saturated bovine lactoferrin nanocapsules (FebLf NCs) in claudin-low, triple-negative breast cancer model. MATERIALS & METHODS: Xenograft study was performed to examine biocompatibility, antitumor efficacy and multimodal nanotheranostic action in combination with near-infrared live mice imaging. RESULTS: FebLf NCs exhibited a size range of 80 nm ± 5 nm with observed superparamagnetism. FebLf NCs successfully internalized into breast cancer cells through receptor-mediated endocytosis and induced apoptosis through the downregulation of inhibitor of apoptosis survivin and livin proteins. Investigations revealed a remarkable biocompatibility, anticancer efficacy of the FebLf NCs. Near-infrared imaging observations confirmed selective localization of multimodal FebLf NCs at the tumor site and lead to time-dependent reduction of tumor growth. CONCLUSION: FebLf NCs can be safe, biocompatible nanotheranostic approach for real-time imaging and monitoring the effect of drugs in real time and have potentials in future clinical trials.
Language eng
DOI 10.2217/nnm.15.199
Field of Research 1004 Medical Biotechnology
1007 Nanotechnology
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Future Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085624

Document type: Journal Article
Collection: School of Medicine
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