The evolutionary ecology of transmissible cancers.

Ujvari, Beata, Gatenby, Robert A and Thomas, Frederic 2016, The evolutionary ecology of transmissible cancers., Infection, genetics and evolution, vol. 39, pp. 293-303, doi: 10.1016/j.meegid.2016.02.005.

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Title The evolutionary ecology of transmissible cancers.
Author(s) Ujvari, BeataORCID iD for Ujvari, Beata
Gatenby, Robert A
Thomas, Frederic
Journal name Infection, genetics and evolution
Volume number 39
Start page 293
End page 303
Total pages 11
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-04
ISSN 1567-7257
Keyword(s) Cancer
Host–parasite interactions
Transmissible cancer
Summary Transmissible tumours, while rare, present a fascinating opportunity to examine the evolutionary dynamics of cancer as both an infectious agent and an exotic, invasive species. Only three naturally-occurring transmissible cancers have been observed so far in the wild: Tasmanian devil facial tumour diseases, canine transmissible venereal tumour, and clam leukaemia. Here, we define four conditions that are necessary and sufficient for direct passage of cancer cells between either vertebrate or invertebrate hosts. Successful transmission requires environment and behaviours that facilitate transfer of tumour cells between hosts including: tumour tissue properties that promote shedding of large numbers of malignant cells, tumour cell plasticity that permits their survival during transmission and growth in a new host, and a 'permissible' host or host tissue. This rare confluence of multiple host- and tumour cell-traits both explains the rarity of tumour cell transmission and provides novel insights into the dynamics that both promote and constrain their growth.
Language eng
DOI 10.1016/j.meegid.2016.02.005
Field of Research 060402 Cell and Nuclear Division
111203 Cancer Genetics
060499 Genetics not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
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