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Maternal mental well-being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate

Mansell, Toby, Vuillermin, Peter, Ponsonby, Anne-Louise, Collier, Fiona, Saffery, Richard and Ryan, Joanne 2016, Maternal mental well-being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate, Development and psychopathology, vol. 28, no. 4 pt2, pp. 1421-1430, doi: 10.1017/S0954579416000183.

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Title Maternal mental well-being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate
Author(s) Mansell, Toby
Vuillermin, Peter
Ponsonby, Anne-Louise
Collier, Fiona
Saffery, Richard
Ryan, Joanne
Journal name Development and psychopathology
Volume number 28
Issue number 4 pt2
Start page 1421
End page 1430
Total pages 10
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2016-11
ISSN 0954-5794
1469-2198
Summary Maternal mental health during pregnancy has been linked to health outcomes in progeny. Mounting evidence implicates fetal “programming” in this process, possibly via epigenetic disruption. Maternal mental health has been associated with glucocorticoid receptor methylation (nuclear receptor subfamily 3, group C, member 1 [NR3C1]) in the neonate; however, most studies have been small (n < 100) and have failed to control for multiple testing in the statistical analysis. The Barwon Infant Study is a population-derived birth cohort with antenatal recruitment. Maternal depression and anxiety were assessed using the Edinburgh Postnatal Depression Scale and psychological distress using the Perceived Stress Scale. NR3C1 cord blood methylation levels were determined using Sequenom MassArray for 481 participants. Maternal psychological distress and anxiety were associated with a small increase in neonate NR3C1 methylation at specific CpG sites, thus replicating some previous findings. However, associations were only nominally significant and did not remain after correction for the number of CpG sites and exposures investigated. As the largest study to explore the relationship between maternal well-being and offspring NR3C1 cord blood methylation, our results highlight the need for caution when interpreting previous findings in this area. Future studies must ensure they are adequately powered to detect the likely small effect sizes while controlling for multiple testing.
Language eng
DOI 10.1017/S0954579416000183
Field of Research 1701 Psychology
1702 Cognitive Science
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Cambridge University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085814

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 01 Sep 2016, 11:13:27 EST

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