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Comparative acoustic performance and mechanical properties of silk membranes for the repair of chronic tympanic membrane perforations

Allardyce, Benjamin J., Rajkhowa, Rangam, Dilley, Rodney J., Xie, Zhigang, Campbell, Luke, Keating, Adrian, Atlas, Marcus D., von Unge, Magnus and Wang, Xungai 2016, Comparative acoustic performance and mechanical properties of silk membranes for the repair of chronic tympanic membrane perforations, Journal of thev mechanical behavior of biomedical materials, vol. 64, pp. 65-74, doi: 10.1016/j.jmbbm.2016.07.017.

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Title Comparative acoustic performance and mechanical properties of silk membranes for the repair of chronic tympanic membrane perforations
Author(s) Allardyce, Benjamin J.ORCID iD for Allardyce, Benjamin J. orcid.org/0000-0003-4009-3371
Rajkhowa, Rangam
Dilley, Rodney J.
Xie, Zhigang
Campbell, Luke
Keating, Adrian
Atlas, Marcus D.
von Unge, Magnus
Wang, Xungai
Journal name Journal of thev mechanical behavior of biomedical materials
Volume number 64
Start page 65
End page 74
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-12
ISSN 1751-6161
1878-0180
Keyword(s) silk
membrane
acoustic
tympanic
perforation
Science & Technology
Technology
Engineering, Biomedical
Materials Science, Biomaterials
Engineering
Materials Science
Summary The acoustic and mechanical properties of silk membranes of different thicknesses were tested to determine their suitability as a repair material for tympanic membrane perforations. Membranes of different thickness (10-100μm) were tested to determine their frequency response and their resistance to pressure loads in a simulated ear canal model. Their mechanical rigidity to pressure loads was confirmed by tensile testing. These membranes were tested alongside animal cartilage, currently the strongest available myringoplasty graft as well as paper, which is commonly used for simpler procedures. Silk membranes showed resonant frequencies within the human hearing range and a higher vibrational amplitude than cartilage, suggesting that silk may offer good acoustic energy transfer characteristics. Silk membranes were also highly resistant to simulated pressure changes in the middle ear, suggesting they can resist retraction, a common cause of graft failure resulting from chronic negative pressures in the middle ear. Part of this strength can be explained by the substantially higher modulus of silk films compared with cartilage. This allows for the production of films that are much thinner than cartilage, with superior acoustic properties, but that still provide the same level of mechanical support as thicker cartilage. Together, these in vitro results suggest that silk membranes may provide good hearing outcomes while offering similar levels of mechanical support to the reconstructed middle ear.
Language eng
DOI 10.1016/j.jmbbm.2016.07.017
Field of Research 090301 Biomaterials
090302 Biomechanical Engineering
091012 Textile Technology
0903 Biomedical Engineering
0912 Materials Engineering
0913 Mechanical Engineering
Socio Economic Objective 860403 Natural Fibres
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085881

Document type: Journal Article
Collection: Institute for Frontier Materials
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