Evolution of cytokine receptor signaling.

Liongue, Clifford, Sertori, Robert and Ward, Alister 2016, Evolution of cytokine receptor signaling., Journal of immunology, vol. 197, no. 1, pp. 11-18, doi: 10.4049/jimmunol.1600372.

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Title Evolution of cytokine receptor signaling.
Author(s) Liongue, CliffordORCID iD for Liongue, Clifford orcid.org/0000-0002-1646-4905
Sertori, Robert
Ward, AlisterORCID iD for Ward, Alister orcid.org/0000-0001-7945-7975
Journal name Journal of immunology
Volume number 197
Issue number 1
Start page 11
End page 18
Total pages 7
Publisher American Association of Immunologists
Place of publication Bethesda, MD
Publication date 2016-07
ISSN 1550-6606
Keyword(s) Evolution
cell–cell communication
intracellular signaling pathways
cellular responses
immune system
Summary Cytokines represent essential mediators of cell-cell communication with particularly important roles within the immune system. These secreted factors are produced in response to developmental and/or environmental cues and act via cognate cytokine receptors on target cells, stimulating specific intracellular signaling pathways to facilitate appropriate cellular responses. This review describes the evolution of cytokine receptor signaling, focusing on the class I and class II receptor families and the downstream JAK-STAT pathway along with its key negative regulators. Individual components generated over a long evolutionary time frame coalesced to form an archetypal signaling pathway in bilateria that was expanded extensively during early vertebrate evolution to establish a substantial "core" signaling network, which has subsequently undergone limited diversification within discrete lineages. The evolution of cytokine receptor signaling parallels that of the immune system, particularly the emergence of adaptive immunity, which has likely been a major evolutionary driver.
Language eng
DOI 10.4049/jimmunol.1600372
Field of Research 110799 Immunology not elsewhere classified
1107 Immunology
Socio Economic Objective 920108 Immune System and Allergy
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085917

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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