Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson's disease and its progression : disease and staging biomarkers and new drug targets.

de Farias, Carine Coneglian, Maes, Michael, Bonifácio, Kamila Landucci, Bortolasci, Chiara Cristina, de Souza Nogueira, Andre, Brinholi, Francis Fregonesi, Matsumoto, Andressa Keiko, do Nascimento, Matheus Amarante, de Melo, Lucio Baena, Nixdorf, Suzana Lucy, Lavado, Edson Lopes, Moreira, Estafania Gastaldello and Barbosa, Decio Sabbatini 2016, Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson's disease and its progression : disease and staging biomarkers and new drug targets., Neuroscience letters, vol. 617, pp. 66-71, doi: 10.1016/j.neulet.2016.02.011.

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Title Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson's disease and its progression : disease and staging biomarkers and new drug targets.
Author(s) de Farias, Carine Coneglian
Maes, Michael
Bonifácio, Kamila Landucci
Bortolasci, Chiara Cristina
de Souza Nogueira, Andre
Brinholi, Francis Fregonesi
Matsumoto, Andressa Keiko
do Nascimento, Matheus Amarante
de Melo, Lucio Baena
Nixdorf, Suzana Lucy
Lavado, Edson Lopes
Moreira, Estafania Gastaldello
Barbosa, Decio Sabbatini
Journal name Neuroscience letters
Volume number 617
Start page 66
End page 71
Total pages 6
Publisher Elsevier B.V.
Place of publication Amsterdam, The Netherlands
Publication date 2016-03
ISSN 1872-7972
Keyword(s) Antioxidants
Malondialdehyde
Oxidative stress
Parkinson disease
Staging
Biomarkers
C-Reactive Protein
Case-Control Studies
Disease Progression
Lipid Peroxidation
Middle Aged
Nitric Oxide
Severity of Illness Index
Neurosciences
Neurosciences & Neurology
Summary There is evidence that immune-inflammatory, stress of reactive oxygen and nitrogen species (IO&NS) processes play a role in the neurodegenerative processes observed in Parkinson's disease (PD). The aim of the present study was to investigate peripheral IO&NS biomarkers in PD. We included 56 healthy individuals and 56 PD patients divided in two groups: early PD stage and late PD stage. Plasma lipid hydroperoxides (LOOH), malondialdehyde (MDA), nitric oxide metabolites (NOx), sulfhydryl (SH) groups, catalase (CAT) activity, superoxide dismutase (SOD) activity, paraoxonase (PON)1 activity, total radical trapping antioxidant parameter (TRAP) and C-reactive protein (CRP) were measured. PD is characterized by increased LOOH, MDA and SOD activity and lowered CAT activity. A combination of five O&NS biomarkers highly significantly predicts PD with a sensitivity of 94.5% and a specificity of 86.8% (i.e., MDA, SOD activity, TRAP, SH-groups and CAT activity). The single best biomarker of PD is MDA, while LOOH and SOD activity are significantly associated with late PD stage, but not early PD stage. Antiparkinson drugs did not affect O&NS biomarkers, but levodopa+carbidopa significantly increased CRP. It is suggested that MDA may serve as a disease biomarker, while LOOH and SOD activity are associated with late PD stage characteristic. New treatments for PD should not only target dopamine but also lipid peroxidation.
Language eng
DOI 10.1016/j.neulet.2016.02.011
Field of Research 1109 Neurosciences
1702 Cognitive Science
1701 Psychology
Socio Economic Objective 920199 Clinical Health (Organs
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085919

Document type: Journal Article
Collection: School of Medicine
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