Hypertension, antihypertensive treatment and cancer incidence and mortality : a pooled collaborative analysis of 12 Australian and New Zealand cohorts

Harding, Jessica L, Sooriyakumaran, Manoshayini, Anstey, Kaarin J, Adams, Robert, Balkau, Beverley, Brennan-Olsen, Sharon, Briffa, Tom, Davis, Timothy ME, Davis, Wendy A, Dobson, Annette, Giles, Graham G, Grant, Janet, Huxley, Rachel, Knuiman, Matthew, Luszcz, Mary, Mitchell, Paul, Pasco, Julie A, Reid, Christopher M, Simmons, David, Simons, Leon A, Taylor, Anne W, Tonkin, Andrew, Woodward, Mark, Shaw, Jonathan E and Magliano, Dianna J 2016, Hypertension, antihypertensive treatment and cancer incidence and mortality : a pooled collaborative analysis of 12 Australian and New Zealand cohorts, Journal of hypertension, vol. 34, no. 1, pp. 149-155, doi: 10.1097/HJH.0000000000000770.

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Title Hypertension, antihypertensive treatment and cancer incidence and mortality : a pooled collaborative analysis of 12 Australian and New Zealand cohorts
Author(s) Harding, Jessica L
Sooriyakumaran, Manoshayini
Anstey, Kaarin J
Adams, Robert
Balkau, Beverley
Brennan-Olsen, Sharon
Briffa, Tom
Davis, Timothy ME
Davis, Wendy A
Dobson, Annette
Giles, Graham G
Grant, Janet
Huxley, Rachel
Knuiman, Matthew
Luszcz, Mary
Mitchell, Paul
Pasco, Julie AORCID iD for Pasco, Julie A orcid.org/0000-0002-8968-4714
Reid, Christopher M
Simmons, David
Simons, Leon A
Taylor, Anne W
Tonkin, Andrew
Woodward, Mark
Shaw, Jonathan E
Magliano, Dianna J
Journal name Journal of hypertension
Volume number 34
Issue number 1
Start page 149
End page 155
Total pages 6
Publisher Wolters Kluwer Health
Place of publication Philadelphia, Penn.
Publication date 2016-01
ISSN 1473-5598
Keyword(s) Adult
Antihypertensive Agents
Databases, Factual
Follow-Up Studies
Middle Aged
New Zealand
Proportional Hazards Models
Risk Factors
Science & Technology
Life Sciences & Biomedicine
Peripheral Vascular Disease
Cardiovascular System & Cardiology
antihypertensive treatment
cancer mortality
Summary BACKGROUND: Observational studies examining associations between hypertension and cancer are inconsistent. We explored the association of hypertension, graded hypertension and antihypertensive treatment with cancer incidence and mortality. METHOD: Eighty-six thousand five hundred and ninety-three participants from the Australian and New Zealand Diabetes and Cancer Collaboration were linked to the National Death Index and Australian Cancer Database. Cox proportional hazards models estimated hazard ratios and 95% confidence intervals (95% CI) for the association of treated and untreated hypertension with cancer incidence and mortality. RESULTS: Over a median follow-up of 15.1 years, 12 070 incident and 4350 fatal cancers were identified. Untreated and treated hypertension, compared with normotension, were associated with an increased risk for cancer incidence [hazard ratio 1.06, 95% CI (1.00-1.11) and 1.09 (1.02-1.16) respectively], and cancer mortality (1.07, 0.98-1.18) and (1.15, 1.03-1.28), respectively. When compared with untreated hypertension, treated hypertension did not have a significantly greater risk for cancer incidence (1.03, 0.97-1.10) or mortality (1.07, 0.97-1.19). A significant dose-response relationship was observed between graded hypertension and cancer incidence and mortality; Ptrend = 0.053 and Ptrend = 0.001, respectively. When stratified by treatment status, these relationships remained significant in untreated, but not in treated, hypertension. CONCLUSION: Hypertension, both treated and untreated, is associated with a modest increased risk for cancer incidence and mortality. Similar risks in treated and untreated hypertension suggest that the increased cancer risk is not explained by the use of antihypertensive treatment.
Language eng
DOI 10.1097/HJH.0000000000000770
Field of Research 1103 Clinical Sciences
1102 Cardiovascular Medicine And Haematology
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Wolters Kluwer Health
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085920

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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