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The ADAMTS hyalectanase family: biological insights from diverse species

Dancevic, Carolyn, McCulloch, Daniel R. and Ward, Alister C. 2016, The ADAMTS hyalectanase family: biological insights from diverse species, Biochemical journal, vol. 473, no. 14, pp. 2011-2022, doi: 10.1042/BCJ20160148.

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Title The ADAMTS hyalectanase family: biological insights from diverse species
Author(s) Dancevic, Carolyn
McCulloch, Daniel R.
Ward, Alister C.ORCID iD for Ward, Alister C. orcid.org/0000-0001-7945-7975
Journal name Biochemical journal
Volume number 473
Issue number 14
Start page 2011
End page 2022
Total pages 12
Publisher Portland Press
Place of publication London, Eng.
Publication date 2016-07-12
ISSN 1470-8728
Keyword(s) a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs (ADAMTS)
embryogenesis
evolution
expression
hyalectan substrates
hyalectanase
Summary The a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs (ADAMTS) family of metzincins are complex secreted proteins that have diverse functions during development. The hyalectanases (ADAMTS1, 4, 5, 8, 9, 15 and 20) are a subset of this family that have enzymatic activity against hyalectan proteoglycans, the processing of which has important implications during development. This review explores the evolution, expression and developmental functions of the ADAMTS family, focusing on the ADAMTS hyalectanases and their substrates in diverse species. This review gives an overview of how the family and their substrates evolved from non-vertebrates to mammals, the expression of the hyalectanases and substrates in different species and their functions during development, and how these functions are conserved across species.
Language eng
DOI 10.1042/BCJ20160148
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085938

Document type: Journal Article
Collection: School of Medicine
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