A study on acute toxicity and solvent capacity of solvate ionic liquids: in vivo using a zebrafish model (Danio rerio)

Yoganantharajah, Prusothman, Eyckens, Daniel J., Pedrina, Jessie L., Henderson, Luke C. and Gibert, Yann 2016, A study on acute toxicity and solvent capacity of solvate ionic liquids: in vivo using a zebrafish model (Danio rerio), New journal of chemistry, vol. 40, no. 8, pp. 6599-6603, doi: 10.1039/c6nj00291a.

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Title A study on acute toxicity and solvent capacity of solvate ionic liquids: in vivo using a zebrafish model (Danio rerio)
Author(s) Yoganantharajah, Prusothman
Eyckens, Daniel J.
Pedrina, Jessie L.
Henderson, Luke C.ORCID iD for Henderson, Luke C. orcid.org/0000-0002-4244-2056
Gibert, Yann
Journal name New journal of chemistry
Volume number 40
Issue number 8
Start page 6599
End page 6603
Total pages 5
Publisher Royal Society of Chemistry
Place of publication Cambridge, Eng.
Publication date 2016-08
ISSN 1144-0546
1369-9261
Keyword(s) Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
Summary Solvate ionic liquids are equimolar solutions of lithium bistrifluoromethylsulfonimide in triglyme (G3TFSA) or tetraglyme (G4TFSA), are a new class of ionic liquids with potential application in a variety of areas such as energy storage in lithium batteries and as a potential alternative to traditional organic solvents. Herein we present the toxicity of G3TFSA and G4TFSA in an in vivo animal model (Danio rerio), and we also present toxicity data for lithium bistrifluoromethylsulfonimide, bmimTFSA, along with tri- and tetra-glyme to give context to the toxicity of the ionic liquids. Moreover we demonstrated that G3TFSA and G4TFSA have similar solvability compared to DMSO to block retinoic acid synthesis during zebrafish embryogenesis using N,N-diethylaminobenzaldehyde (DEAB). The findings show that, when used in this capacity, DEAB has the same biological effect with no difference in off-target toxicity, validating these ionic liquids as potential replacements for DMSO.
Language eng
DOI 10.1039/c6nj00291a
Field of Research 030299 Inorganic Chemistry not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Royal Society of Chemistry and the Centre national de la Recherche Scientifique
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085961

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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