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Anti-inflammatory activity and mechanisms of a lipid extract from hard-shelled mussel (mytilus coruscus) in mice with dextran sulphate sodium-induced colitis

Wang, Fenglei, Fu, Yuanqing, Cai, Wenwen, Sinclair, Andrew J and Li, Duo 2016, Anti-inflammatory activity and mechanisms of a lipid extract from hard-shelled mussel (mytilus coruscus) in mice with dextran sulphate sodium-induced colitis, Journal of functional foods, vol. 23, pp. 389-399, doi: 10.1016/j.jff.2016.03.002.

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Title Anti-inflammatory activity and mechanisms of a lipid extract from hard-shelled mussel (mytilus coruscus) in mice with dextran sulphate sodium-induced colitis
Author(s) Wang, Fenglei
Fu, Yuanqing
Cai, Wenwen
Sinclair, Andrew J
Li, Duo
Journal name Journal of functional foods
Volume number 23
Start page 389
End page 399
Total pages 11
Publisher Elsevier
Place of publication London, Eng.
Publication date 2016-05
ISSN 1756-4646
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Food Science & Technology
Hard-shelled mussel
Lipid extract
Salicylazosulphapyridine
Colitis
Anti-inflammatory
TLR-4/NF-kappa B pathway
INFLAMMATORY-BOWEL-DISEASE
GREEN-LIPPED MUSSEL
ULCERATIVE-COLITIS
PERNA-CANALICULUS
FATTY-ACIDS
FISH-OIL
KAPPA-B
RATS
THERAPY
ARTHRITIS
Summary The anti-inflammatory effect of a lipid extract from hard-shelled mussel (HMLE) on dextran sulphate sodium (DSS)-induced colitis in mice was investigated. Salicylazosulphapyridine (SASP) and different doses of HMLE were administered by gastric gavage. HMLE significantly attenuated DSS-induced colitis disease activity index scores, tissue damage, splenic enlargement and colon myeloperoxidase accumulation. In addition, HMLE improved colon oxidative stress and production and expression of anti-inflammatory cytokine, interleukin (IL)-10, while HMLE inhibited the abnormal productions and mRNA expressions of pro-inflammatory cytokines, namely tumour necrosis factor-α, IL-1β, and IL-6, as well as the expression of key molecules in the toll-like receptor (TLR)-4/nuclear factor (NF)-κB signalling pathway. These findings suggest that HMLE has an anti-inflammatory effect on DSS-induced colitis, equivalent to that of SASP, and this effect might be related to the regulation of inflammatory mediators and key molecules in the TLR-4/NF-κB pathway.
Language eng
DOI 10.1016/j.jff.2016.03.002
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
1111 Nutrition And Dietetics
0908 Food Sciences
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085962

Document type: Journal Article
Collection: School of Medicine
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