Non-hip and non-vertebral fractures : the neglected fracture sites

Holloway, KL, Henry, MJ, Brennan-Olsen, SL, Bucki-Smith, G, Nicholson, GC, Korn, S, Sanders, KM, Pasco, JA and Kotowicz, MA 2016, Non-hip and non-vertebral fractures : the neglected fracture sites, Osteoporosis international, vol. 27, no. 3, pp. 905-913, doi: 10.1007/s00198-015-3322-8.

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Title Non-hip and non-vertebral fractures : the neglected fracture sites
Author(s) Holloway, KLORCID iD for Holloway, KL orcid.org/0000-0001-5064-2990
Henry, MJ
Brennan-Olsen, SL
Bucki-Smith, G
Nicholson, GC
Korn, S
Sanders, KM
Pasco, JAORCID iD for Pasco, JA orcid.org/0000-0002-8968-4714
Kotowicz, MAORCID iD for Kotowicz, MA orcid.org/0000-0002-8094-1411
Journal name Osteoporosis international
Volume number 27
Issue number 3
Start page 905
End page 913
Total pages 9
Publisher Springer
Place of publication Berlin, Germany.
Publication date 2016-03
ISSN 0937-941X
1433-2965
Summary Summary: Non-hip, non-vertebral fractures (NHNVF) were compared with hip, vertebral and controls. NHNVF were younger and heavier than controls and hip/vertebral fractures in both men and women, respectively. Falls and prior fractures were less common in NHNVF than hip fractures. Glucocorticoid use was lower in NHNVF compared to vertebral fracture (VF) in men. Introduction: Although hip fracture (HF) and vertebral fractures (VF) receive the most attention in the literature and are the targeted sites for fracture prevention, non-hip, non-vertebral fracture (NHNVF) sites account for a greater proportion of fractures than the hip or vertebrae. This study aimed to assess risk factors for NHNVF and compare them with those for HF, VF and controls. Methods: Incident fractures during 2005–2007 for men and 1994–1996 for women were identified using computerised keyword searches of radiological reports, and controls were selected at random from electoral rolls for participation in the Geelong Osteoporosis Study. Participants aged 60+ years were included in this study. Results: Compared to controls, men and women with NHNVF were younger (ORs, 0.90, 95 % CI 0.86–0.94; and 0.96, 0.93–0.98, respectively) and had a lower femoral neck bone mineral density (BMD) T-score (age-adjusted; difference [men] 0.383, P = 0.002; [women] 0.287, P = 0.001). Compared to HF, men and women with NHNVF were heavier (difference [men] 9.0 kg, P = 0.01; [women] 7.6 kg, P < 0.001). Heavier weight was also a risk factor for women with NHNVF compared to VF (1.03, 1.01–1.06). In men with NHNVF, falls (0.37, 0.14–0.97) and prior fractures (0.38, 0.15–0.98) were less common compared to HF; and glucocorticoid use was less common for NHNVF (0.30, 0.11–0.85) compared to VF. Conclusions: Given the high numbers of NHNVF sustained by men and women in this study, fracture prevention strategies should focus on individuals with high risk of sustaining these types of fractures, as well as on individuals who are more likely to sustain a HF or VF.
Language eng
DOI 10.1007/s00198-015-3322-8
Field of Research 110399 Clinical Sciences not elsewhere classified
1103 Clinical Sciences
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, International Osteoporosis Foundation and National Osteoporosis Foundation
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085969

Document type: Journal Article
Collection: School of Medicine
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