Short update on docosapentaenoic acid: a bioactive long-chain n-3 fatty acid

Kaur, Gunveen, Guo, Xiao-Fei and Sinclair, Andrew J. 2016, Short update on docosapentaenoic acid: a bioactive long-chain n-3 fatty acid, Current opinion in clinical nutrition and metabolic care, vol. 19, no. 2, pp. 88-91, doi: 10.1097/MCO.0000000000000252.

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Title Short update on docosapentaenoic acid: a bioactive long-chain n-3 fatty acid
Author(s) Kaur, GunveenORCID iD for Kaur, Gunveen
Guo, Xiao-Fei
Sinclair, Andrew J.
Journal name Current opinion in clinical nutrition and metabolic care
Volume number 19
Issue number 2
Start page 88
End page 91
Total pages 4
Publisher Lippincott, Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2016-03
ISSN 1473-6519
Keyword(s) n-3 docosapentaenoic acid
w-3 fatty acids
polyunsaturated fatty acids
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Nutrition & Dietetics
omega-3 fatty acids
Summary PURPOSE OF REVIEW: Docosapentaenoic acid (DPA) is a long-chain n-3 polyunsaturated fatty acid that is intermediary between eicosapentaenoic acid and docosahexaenoic acid in the n-3 synthesis pathway. DPA is part of our normal diet through fish and lean red meat. In recent years, DPA has received increasing attention as an important bioactive fatty acid in light of its potential beneficial health effects, which include anti-inflammatory actions, antiplatelet aggregation, and improved plasma lipid prolife. This review provides a short summary of the most recent research on DPA. RECENT FINDINGS: In this review, we report on the latest association data as well as data generated from in-vitro and in-vivo studies on DPA and cardiovascular health, mental health, inflammation, and cancer. We also report on the newly identified DPA metabolites and their effects on exacerbation of inflammation in animal models. SUMMARY: Although there is a growing body of evidence supporting DPA's role as an important bioactive fatty acid, there is a need for more 'cause and effect studies', clinical trials and studies which can reveal whether DPA plays separate roles to those identified for eicosapentaenoic acid and docosahexaenoic acid.
Language eng
DOI 10.1097/MCO.0000000000000252
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, Wolters Kluwer Health
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