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Protozoa lectins and their role in host-pathogen interactions

Singh, Ram Sarup, Walia, Amandeep Kaur and Kanwar, Jagat Rakesh 2016, Protozoa lectins and their role in host-pathogen interactions, Biotechnology advances, vol. 34, no. 5, pp. 1018-1029, doi: 10.1016/j.biotechadv.2016.06.002.

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Title Protozoa lectins and their role in host-pathogen interactions
Author(s) Singh, Ram Sarup
Walia, Amandeep Kaur
Kanwar, Jagat RakeshORCID iD for Kanwar, Jagat Rakesh orcid.org/0000-0003-3728-9568
Journal name Biotechnology advances
Volume number 34
Issue number 5
Start page 1018
End page 1029
Total pages 12
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-09
ISSN 1873-1899
Keyword(s) Acanthamoeba
Adhesion molecules
Cryptosporidium
Entamoeba
Giardia
Haemagglutination
Host–pathogen
Lectin
Protozoa
Tritrichomonas
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Host-pathogen
Summary Lectins are proteins/glycoproteins of non-immune origin that agglutinate red blood cells, lymphocytes, fibroblasts, etc., and bind reversibly to carbohydrates present on the apposing cells. They have at least two carbohydrate binding sites and their binding can be inhibited by one or more carbohydrates. Owing to carbohydrate binding specificity of lectins, they mediate cell-cell interactions and play role in protozoan adhesion and host cell cytotoxicity, thus are central to the pathogenic property of the parasite. Several parasitic protozoa possess lectins which mediate parasite adherence to host cells based on their carbohydrate specificities. These interactions could be exploited for development of novel therapeutics, targeting the adherence and thus helpful in eradicating wide spread of protozoan diseases. The current review highlights the present state knowledge with regard to protozoal lectins with an emphasis on their haemagglutination activity, carbohydrate specificity, characteristics and also their role in pathogenesis notably as adhesion molecules, thereby aiding the pathogen in disease establishment.
Language eng
DOI 10.1016/j.biotechadv.2016.06.002
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085979

Document type: Journal Article
Collection: School of Medicine
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