Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water

He, Ping, Haswell, Stephen J., Pamme, Nicole and Archibald, Stephen J. 2014, Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water, Applied Radiation and Isotopes, vol. 91, pp. 64-70, doi: 10.1016/j.apradiso.2014.04.021.

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Title Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water
Author(s) He, Ping
Haswell, Stephen J.
Pamme, Nicole
Archibald, Stephen J.
Journal name Applied Radiation and Isotopes
Volume number 91
Start page 64
End page 70
Total pages 7
Publisher Pergamon Press
Place of publication Oxford, Eng.
Publication date 2014-09
ISSN 0969-8043
Keyword(s) electrochemical cell
positron emission tomography
radiochemical synthesis
Summary Positron emission tomography (PET) is a powerful scientific and clinical tool for the study and visualization of human physiology that can provide important information about metabolism and diseases such as cancer. At present, [18F]fluorodeoxyglucose ([18F]FDG) is the most frequently used radiotracer for the routine clinical evaluation of malignant tumors in a range of body tissues. FDG synthesis is continuously being developed to improve and simplify the synthetic procedure including the isolation of [18F]fluoride from [18O]water. There are many methods reported in literature for the isolation of [18F]fluoride, including evaporation, coat-capture–elution, the use of cation-exchange resin and electrode trapping. This review article gives an overview of some of the most common methods for the separation of [18F]fluoride ions from [18O]water, highlighting the potential strength of the methods and also problems and weaknesses for synthesis of 18F PET tracers.
Language eng
DOI 10.1016/j.apradiso.2014.04.021
Field of Research 110103 Medical Biochemistry: Inorganic Elements and Compounds
0202 Atomic, Molecular, Nuclear, Particle And Plasma Physics
1103 Clinical Sciences
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
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Document type: Journal Article
Collection: Faculty of Science, Engineering and Built Environment
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