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Maternal creatine supplementation during pregnancy prevents acute and long-term deficits in skeletal muscle after birth asphyxia: a study of structure and function of hind limb muscle in the spiny mouse

LaRosa, Domenic A., Ellery, Stacey J., Snow, Rod J., Walker, David W. and Dickinson, Hayley 2016, Maternal creatine supplementation during pregnancy prevents acute and long-term deficits in skeletal muscle after birth asphyxia: a study of structure and function of hind limb muscle in the spiny mouse, Pediatric research, vol. 80, no. 6, pp. 852-860, doi: 10.1038/pr.2016.153.

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Title Maternal creatine supplementation during pregnancy prevents acute and long-term deficits in skeletal muscle after birth asphyxia: a study of structure and function of hind limb muscle in the spiny mouse
Author(s) LaRosa, Domenic A.
Ellery, Stacey J.
Snow, Rod J.ORCID iD for Snow, Rod J. orcid.org/0000-0002-4796-6916
Walker, David W.
Dickinson, Hayley
Journal name Pediatric research
Volume number 80
Issue number 6
Start page 852
End page 860
Total pages 9
Publisher Nature Publishing Group
Place of publication New York, N.Y.
Publication date 2016-12
ISSN 0031-3998
1530-0447
Summary BACKGROUND: Maternal antenatal creatine supplementation protects the brain, kidney, and diaphragm against the effects of birth asphyxia in the spiny mouse. In this study, we examined creatine's potential to prevent damage to axial skeletal muscles.

METHODS: Pregnant spiny mice were fed a control or creatine-supplemented diet from mid-pregnancy, and 1 d before term (39 d), fetuses were delivered by c-section with or without 7.5 min of birth asphyxia. At 24 h or 33 ± 2 d after birth, gastrocnemius muscles were obtained for ex-vivo study of twitch-tension, muscle fatigue, and structural and histochemical analysis.

RESULTS: Birth asphyxia significantly reduced cross-sectional area of all muscle fiber types (P < 0.05), and increased fatigue caused by repeated tetanic contractions at 24 h of age (P < 0.05). There were fewer (P < 0.05) Type I and IIa fibers and more (P < 0.05) Type IIb fibers in male gastrocnemius at 33 d of age. Muscle oxidative capacity was reduced (P < 0.05) in males at 24 h and 33 d and in females at 24 h only. Maternal creatine treatment prevented all asphyxia-induced changes in the gastrocnemius, improved motor performance.

CONCLUSION: This study demonstrates that creatine loading before birth protects the muscle from asphyxia-induced damage at birth.
Language eng
DOI 10.1038/pr.2016.153
Field of Research 111401 Foetal Development and Medicine
1114 Paediatrics And Reproductive Medicine
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, International Pediatric Research Foundation
Persistent URL http://hdl.handle.net/10536/DRO/DU:30085995

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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Created: Thu, 08 Sep 2016, 09:37:30 EST

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