Industrial lab-on-a-chip: design, applications and scale-up for drug discovery and delivery

Vladisavljević, Goran T., Khalid, Nauman, Neves, Marcos A., Kuroiwa, Takashi, Nakajima, Mitsutoshi, Uemura, Kunihiko, Ichikawa, Sosaku and Kobayashi, Isao 2013, Industrial lab-on-a-chip: design, applications and scale-up for drug discovery and delivery, Advanced drug delivery reviews, vol. 65, no. 11-12, pp. 1626-1663, doi: 10.1016/j.addr.2013.07.017.

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Title Industrial lab-on-a-chip: design, applications and scale-up for drug discovery and delivery
Author(s) Vladisavljević, Goran T.
Khalid, NaumanORCID iD for Khalid, Nauman
Neves, Marcos A.
Kuroiwa, Takashi
Nakajima, Mitsutoshi
Uemura, Kunihiko
Ichikawa, Sosaku
Kobayashi, Isao
Journal name Advanced drug delivery reviews
Volume number 65
Issue number 11-12
Start page 1626
End page 1663
Total pages 38
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2013-11-15
ISSN 1872-8294
Keyword(s) microfluidics
device fabrication
unit operation
monodisperse droplets
parallel flow
functional materials
biological processing
Summary Microfluidics is an emerging and promising interdisciplinary technology which offers powerful platforms for precise production of novel functional materials (e.g., emulsion droplets, microcapsules, and nanoparticles as drug delivery vehicles- and drug molecules) as well as high-throughput analyses (e.g., bioassays, detection, and diagnostics). In particular, multiphase microfluidics is a rapidly growing technology and has beneficial applications in various fields including biomedicals, chemicals, and foods. In this review, we first describe the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition. We next describe some microfluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. We also highlight and discuss design, applications and scale up of droplet- and flow-based microfluidic devices used for drug discovery and delivery.
Language eng
DOI 10.1016/j.addr.2013.07.017
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
100706 Nanofabrication, Growth and Self Assembly
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 860899 Human Pharmaceutical Products not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, Elsevier BV
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