Antibacterial activity of the venom of Heterometrus xanthopus
Ahmed, Umair, Mujaddad-ur-Rehman, Malik, Khalid, Nauman, Fawad, Sardar Atiq and Fatima, Anees 2012, Antibacterial activity of the venom of Heterometrus xanthopus, Indian journal of pharmacology, vol. 44, no. 4, pp. 509-511, doi: 10.4103/0253-7613.99332.
Heterometrus xanthopus (Scorpion) is one of the most venomous and ancient arthropods. Its venom contains anti-microbial peptides like hadrurin, scorpine, Pandinin 1, and Pandinin 2 that are able to effectively kill multidrug-resistant pathogens. The present study was conducted to evaluate the anti-bacterial activity of H. xanthopus venom. Six Gram-positive and Gram-negative bacterial strains were tested against 1/100, 1/10, and 1/1 fractions of distilled water diluted and crude venom. 1/100 and 1/10 dilutions were not successful in any of the six bacterial strains studied while the 1/1 dilution was effective on Bacillus subtilis ATCC 6633, Salmonella typhimurium ATCC 14028, and Pseudomonas aeruginosa ATCC 27853 with highest zone of inhibition were obtained on B. subtilis. Crude venom was effective against Enterococcus faecalis ATCC 14506, B. subtilis, S. typhimurium, and P. aeruginosa. The most effective results were observed on B. subtilis.
Field of Research
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified 1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective
860899 Human Pharmaceutical Products not elsewhere classified
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