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Performance analysis of a field-effect-transistor based aptasensor

Saiful Islam, Md., Coyle, Eugene D and Kouzani, Abbas 2016, Performance analysis of a field-effect-transistor based aptasensorMicroelectronics, electromagnetics and telecommunications, Springer, Amsterdam, The Netherlands, pp.767-775, doi: 10.1007/978-81-322-2728-1_73.

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Title Performance analysis of a field-effect-transistor based aptasensor
Author(s) Saiful Islam, Md.
Coyle, Eugene D
Kouzani, Abbas
Title of book Microelectronics, electromagnetics and telecommunications
Publication date 2016
Start page 767
End page 775
Total pages 9
Publisher Springer
Place of Publication Amsterdam, The Netherlands
Keyword(s) Field-effect-transistor
Biosensor
Aptamer
Aptasensor
Summary Prostate cancer is one of the most diagnosed cancers which leads to a considerable number of deaths due to the lack of early and sensitive detection. This paper presents an aptamer functionalized field effect (FET) based biosensor for the detection of prostate cancer. Prostate specific antigen (PSA) is considered as the biomarker for prostate cancer whose detection is confirmed by attaching aptamers onto the sensor surface. Through the modelling and numerical simulation, the paper aims to evaluate and predict the performance parameters such as sensitivity, settling time, and limit of detection (LOD) of a label-free FET based electronic biosensor. Various sensor parameters such as structure (i.e., geometry), type of the FET (e.g., nanowire FET, spherical FET, ion-selective FET, and magnetic particle) radius of the FET channel and incubation time are optimized and analyzed. In addition, concentration of analyte biomolecules, diffusion coefficients and affinity to the receptor molecules are also investigated to determine the optimize performance parameters.
ISBN 9788132227267
ISSN 1876-1100
1876-1119
Language eng
DOI 10.1007/978-81-322-2728-1_73
Field of Research 090304 Medical Devices
Socio Economic Objective 861502 Medical Instruments
HERDC Research category B1 Book chapter
ERA Research output type B Book chapter
Copyright notice ©2016, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086174

Document type: Book Chapter
Collection: School of Engineering
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