Voluntary saccades in attention-deficit/hyperactivity disorder: looking into the relationship between motor impairment and Autism Spectrum Disorder symptoms

Connolly, Amanda J., Rinehart, Nicole J., Johnson, Beth, Papadopoulos, Nicole and Fielding, Joanne 2016, Voluntary saccades in attention-deficit/hyperactivity disorder: looking into the relationship between motor impairment and Autism Spectrum Disorder symptoms, Neuroscience, vol. 334, pp. 47-54, doi: 10.1016/j.neuroscience.2016.07.013.

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Title Voluntary saccades in attention-deficit/hyperactivity disorder: looking into the relationship between motor impairment and Autism Spectrum Disorder symptoms
Author(s) Connolly, Amanda J.
Rinehart, Nicole J.ORCID iD for Rinehart, Nicole J. orcid.org/0000-0001-6109-3958
Johnson, Beth
Papadopoulos, NicoleORCID iD for Papadopoulos, Nicole orcid.org/0000-0001-9057-1672
Fielding, Joanne
Journal name Neuroscience
Volume number 334
Start page 47
End page 54
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-10-15
ISSN 0306-4522
1873-7544
Keyword(s) Attention Deficit Hyperactivity Disorder
motor
Autism Spectrum Disorder
voluntary saccades
cerebellum
Summary Although there is little overlap in core diagnostic criteria for ADHD and Autism Spectrum Disorder (ASD), ASD symptoms are estimated to co-occur in children with ADHD in 20-50% of cases. As motor control deficits are common to both disorders, we investigated the impact of ASD symptoms on ocular motor control in children with Attention Deficit Hyperactivity Disorder-Combined Type (ADHD-CT), using a cued saccade paradigm sensitive to cerebellar ocular motor impairment in ASD. Basic saccade metrics (latency, velocity and accuracy), trial-to-trial variability, and main sequences relationships (saccade velocity for a given amplitude) were assessed, for 14 males with ADHD-CT and 14 typically developing (TD) males (aged 8-14, IQ>80). Our results revealed that saccade profiles of the ADHD-CT group showed a pattern of hypermetria and altered main sequence. As the cerebellum is crucially involved in the regulation of saccade parameters, we propose that this pattern of deficit in ADHD-CT is consistent with the widely reported morphological abnormalities in ocular motor vermis (cerebellar lobules VI-VII) in ADHD-CT and ASD.
Language eng
DOI 10.1016/j.neuroscience.2016.07.013
Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified
1109 Neurosciences
1701 Psychology
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086210

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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