Discharge patterns of human tensor palatini motor units during sleep onset

Nicholas, Christian L., Jordan, Amy S., Heckel, Leila, Worsnop, Christopher, Bei, Bei, Saboisky, Julian P., Eckert, Danny J., White, David P., Malhotra, Atul and Trinder, John 2012, Discharge patterns of human tensor palatini motor units during sleep onset, SLEEP, vol. 35, no. 5, pp. 699-707, doi: 10.5665/sleep.1834.

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Title Discharge patterns of human tensor palatini motor units during sleep onset
Author(s) Nicholas, Christian L.
Jordan, Amy S.
Heckel, LeilaORCID iD for Heckel, Leila orcid.org/0000-0002-9138-1034
Worsnop, Christopher
Bei, Bei
Saboisky, Julian P.
Eckert, Danny J.
White, David P.
Malhotra, Atul
Trinder, John
Journal name SLEEP
Volume number 35
Issue number 5
Start page 699
End page 707
Total pages 9
Publisher Sleep Research Society
Place of publication Darien, Ill.
Publication date 2012-05
ISSN 1550-9109
Keyword(s) sleep
upper airways muscles
obstructive sleep apnea
Summary Study Objectives: Upper airway muscles such as genioglossus (GG) and tensor palatini (TP) reduce activity at sleep onset. In GG reduced muscle activity is primarily due to inspiratory modulated motor units becoming silent, suggesting reduced respiratory pattern generator (RPG) output. However, unlike GG, TP shows minimal respiratory modulation and presumably has few inspiratory modulated motor units and minimal input from the RPG. Thus, we investigated the mechanism by which TP reduces activity at sleep onset.

Design: The activity of TP motor units were studied during relaxed wakefulness and over the transition from wakefulness to sleep.

Setting: Sleep laboratory.

Participants: Nine young (21.4 ± 3.4 years) males were studied on a total of 11 nights.

Intervention: Sleep onset.

Measurements and Results: Two TP EMGs (thin, hooked wire electrodes), and sleep and respiratory measures were recorded. One hundred twenty-one sleep onsets were identified (13.4 ± 7.2/subject), resulting in 128 motor units (14.3 ± 13.0/subject); 29% of units were tonic, 43% inspiratory modulated (inspiratory phasic 18%, inspiratory tonic 25%), and 28% expiratory modulated (expiratory phasic 21%, expiratory tonic 7%). There was a reduction in both expiratory and inspiratory modulated units, but not tonic units, at sleep onset. Reduced TP activity was almost entirely due to de-recruitment.

Conclusions: TP showed a similar distribution of motor units as other airway muscles. However, a greater proportion of expiratory modulated motor units were active in TP and these expiratory units, along with inspiratory units, tended to become silent over sleep onset. The data suggest that both expiratory and inspiratory drive components from the RPG are reduced at sleep onset in TP.
Language eng
DOI 10.5665/sleep.1834
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, Sleep Research Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086250

Document type: Journal Article
Collections: Faculty of Health
School of Nursing and Midwifery
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