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The impact of HLA-G 3' UTR variants and sHLA-G on risk and clinical correlates of schizophrenia

Rajasekaran, Aahwini, Shivakumar, Venkataram, Kalmady, Sunil V., Narayanaswamy, Janardhanan C., Subbana, Manjula, Venugopal, Deepthi, Amaresha, Anekal C., Venkatasubramanian, Ganesan, Berk, Michael and Debnath, Monojit 2016, The impact of HLA-G 3' UTR variants and sHLA-G on risk and clinical correlates of schizophrenia, Human immunology, vol. 77, no. 12, pp. 1166-1171, doi: 10.1016/j.humimm.2016.08.013.

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Title The impact of HLA-G 3' UTR variants and sHLA-G on risk and clinical correlates of schizophrenia
Author(s) Rajasekaran, Aahwini
Shivakumar, Venkataram
Kalmady, Sunil V.
Narayanaswamy, Janardhanan C.
Subbana, Manjula
Venugopal, Deepthi
Amaresha, Anekal C.
Venkatasubramanian, Ganesan
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Debnath, Monojit
Journal name Human immunology
Volume number 77
Issue number 12
Start page 1166
End page 1171
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-12
ISSN 1879-1166
Keyword(s) Development
HLA-G
Hallucinations
Infection
Inflammation
Schizophrenia
Science & Technology
Life Sciences & Biomedicine
Immunology
LEUKOCYTE ANTIGEN-G
HUMAN CYTOMEGALOVIRUS-INFECTION
MATERNAL IMMUNE ACTIVATION
G MESSENGER-RNA
G EXPRESSION
EARLY-ONSET
G GENE
INSERTION/DELETION POLYMORPHISM
NEURODEVELOPMENTAL ORIGIN
AUDITORY HALLUCINATIONS
Summary The Major Histocompatibility Complex (MHC)/Human Leukocyte Antigen (HLA) is known to influence the pathogenesis of several complex human diseases resulting from gene-environmental interactions. Recently, it has emerged as one of the risk determinants of schizophrenia. The HLA-G protein (a non-classical MHC class I molecule), encoded by the HLA-G gene, is shown to play important role in embryonic development. Importantly, its genetic variations and aberrant expression have been implicated in pregnancy complications like preeclampsia, inflammation, and autoimmunity. Converging evidence implicates these phenomena as risk mechanisms of schizophrenia. However, the functional implications of HLA-G in schizophrenia are yet to be empirically examined. The impact of two functional polymorphisms [14bp Insertion/Deletion (INDEL) and +3187 A>G] and soluble HLA-G (sHLA-G) levels on schizophrenia risk was evaluated. In this exploratory study, the Ins/Ins genotype of 14bp INDEL was found to confer a strong risk for schizophrenia. Further, low levels of sHLA-G were shown to have a significant impact on Clinical Global Impression (CGI) severity in people with schizophrenia.
Language eng
DOI 10.1016/j.humimm.2016.08.013
Field of Research 110799 Immunology not elsewhere classified
1107 Immunology
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, American Society for Histocompatibility and Immunogenetics
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086684

Document type: Journal Article
Collection: School of Medicine
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