Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology

Data-Franco, Joao, Singh, Ajeet, Popovic, Dina, Ashton, Melanie, Berk, Michael, Vieta, Eduard, Figueira, M. L. and Dean, Olivia M. 2017, Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology, Progress in neuro-psychopharmacology & biological psychiatry, vol. 72, pp. 73-86, doi: 10.1016/j.pnpbp.2016.09.004.

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Title Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology
Author(s) Data-Franco, Joao
Singh, Ajeet
Popovic, Dina
Ashton, MelanieORCID iD for Ashton, Melanie orcid.org/0000-0001-6832-4157
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Vieta, Eduard
Figueira, M. L.
Dean, Olivia M.ORCID iD for Dean, Olivia M. orcid.org/0000-0002-2776-3935
Journal name Progress in neuro-psychopharmacology & biological psychiatry
Volume number 72
Start page 73
End page 86
Total pages 14
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-01-04
ISSN 0278-5846
1878-4216
Keyword(s) Bipolar disorder
Inflammation
Minocycline
Mitochondrial dysfunction
Neurogenesis
Novel therapy
Oxidative stress
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Pharmacology & Pharmacy
Psychiatry
Neurosciences & Neurology
MAGNETIC-RESONANCE-SPECTROSCOPY
SINGLE KETAMINE INFUSION
PLACEBO-CONTROLLED TRIAL
MAJOR DEPRESSIVE DISORDER
D-ASPARTATE RECEPTOR
N-ACETYL CYSTEINE
PLATELET INTRACELLULAR CALCIUM
POSTMORTEM PREFRONTAL CORTEX
OXIDATIVE STRESS PARAMETERS
MOOD STABILIZERS LITHIUM
Summary Multiple novel biological mechanisms putatively involved in the etiology of bipolar disorders are being explored. These include oxidative stress, altered glutamatergic neurotransmission, mitochondrial dysfunction, inflammation, cell signaling, apoptosis and impaired neurogenesis. Important clinical translational potential exists for such mechanisms to help underpin development of novel therapeutics - much needed given limitations of current therapies. These new mechanisms also help improve our understanding of how current therapeutics might exert their effects. Lithium, for example, appears to have antioxidant, immunomodulatory, signaling, anti-apoptotic and neuroprotective properties. Similar properties have been attributed to other mood stabilizers such as valproate, lamotrigine, and quetiapine. Perhaps of greatest translational value has been the recognition of such mechanisms leading to the emergence of novel therapeutics for bipolar disorders. These include the antioxidant N-acetylcysteine, the anti-inflammatory celecoxib, and ketamine - with effects on the glutamatergic system and microglial inhibition. We review these novel mechanisms and emerging therapeutics, and comment on next steps in this space.
Language eng
DOI 10.1016/j.pnpbp.2016.09.004
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086686

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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