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Hepcidin is a better predictor of iron stores in premenopausal women than blood loss or dietary intake

Lim, Karen H.C., Booth, Alison O., Nowson, Caryl A., Szymlek-Gay, Ewa A., Irving, David O. and Riddell, Lynn J. 2016, Hepcidin is a better predictor of iron stores in premenopausal women than blood loss or dietary intake, Nutrients, vol. 8, no. 9, Article Number : 540, pp. 1-15, doi: 10.3390/nu8090540.

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Title Hepcidin is a better predictor of iron stores in premenopausal women than blood loss or dietary intake
Author(s) Lim, Karen H.C.
Booth, Alison O.ORCID iD for Booth, Alison O. orcid.org/0000-0003-4914-7006
Nowson, Caryl A.ORCID iD for Nowson, Caryl A. orcid.org/0000-0001-6586-7965
Szymlek-Gay, Ewa A.ORCID iD for Szymlek-Gay, Ewa A. orcid.org/0000-0002-6533-7945
Irving, David O.
Riddell, Lynn J.ORCID iD for Riddell, Lynn J. orcid.org/0000-0002-0688-2134
Journal name Nutrients
Volume number 8
Issue number 9
Season Article Number : 540
Start page 1
End page 15
Total pages 15
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2016
ISSN 2072-6643
Keyword(s) blood donation
female
hepcidin
iron intake
iron status
menstrual loss
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
YOUNG-WOMEN
SERUM HEPCIDIN
NONHEME-IRON
ADULT WOMEN
NEW-ZEALAND
ABSORPTION
DEFICIENCY
SUPPLEMENTATION
METAANALYSIS
FOOD
Summary The relationship between dietary intake, circulating hepcidin and iron status in free-living premenopausal women has not been explored. This cross-sectional study aimed to identify dietary determinants of iron stores after accounting for blood loss and to determine whether iron intake predicts iron stores independently of hepcidin in a sample of Australian women. Three hundred thirty eight women aged 18-50 years were recruited. Total intake and food sources of iron were determined via food frequency questionnaire; the magnitude of menstrual losses was estimated by self-report; and blood donation volume was quantified using blood donation records and self-reported donation frequency. Serum samples were analysed for ferritin, hepcidin and C-reactive protein concentrations. Linear regression was used to investigate associations. Accounting for blood loss, each 1 mg/day increase in dietary iron was associated with a 3% increase in iron stores (p = 0.027); this association was not independent of hepcidin. Hepcidin was a more influential determinant of iron stores than blood loss and dietary factors combined (R² of model including hepcidin = 0.65; R² of model excluding hepcidin = 0.17, p for difference <0.001), and increased hepcidin diminished the positive association between iron intake and iron stores. Despite not being the biggest contributor to dietary iron intake, unprocessed meat was positively associated with iron stores, and each 10% increase in consumption was associated with a 1% increase in iron stores (p = 0.006). No other dietary factors were associated with iron stores. Interventions that reduce hepcidin production combined with dietary strategies to increase iron intake may be important means of improving iron status in women with depleted iron stores.
Language eng
DOI 10.3390/nu8090540
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
1111 Nutrition And Dietetics
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086694

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.