Past physical activity and age-related macular degeneration: the Melbourne Collaborative Cohort Study McGuinness, Myra B., Karahalios, Amalia, Simpson, Julie A., Guymer, Robyn H., Robman, Luba D., Hodge, Allison M., Cerin, Ester, Giles, Graham G. and Finger, Robert P. 2016, Past physical activity and age-related macular degeneration: the Melbourne Collaborative Cohort Study, British journal of ophthalmology, vol. 100, no. 10, pp. 1353-1358, doi: 10.1136/bjophthalmol-2015-307663. Attached Files Name Description MIMEType Size Downloads Title Past physical activity and age-related macular degeneration: the Melbourne Collaborative Cohort Study Author(s) McGuinness, Myra B. Karahalios, Amalia Simpson, Julie A. Guymer, Robyn H. Robman, Luba D. Hodge, Allison M. Cerin, Ester Giles, Graham G. Finger, Robert P. Journal name British journal of ophthalmology Volume number 100 Issue number 10 Start page 1353 End page 1358 Total pages 7 Publisher BMJ Place of publication London, Eng. Publication date 2016-10 ISSN 1468-2079 Keyword(s) Epidemiology Macula Neovascularisation Retina Summary BACKGROUND/AIMS: To assess the association between past physical activity and early, intermediate and late age-related macular degeneration (AMD) in a community-based cohort study in Melbourne, Australia. METHODS: Diet and lifestyle information was recorded at baseline (1990-1994) and total recreational activity was derived from walking, vigorous and non-vigorous exercise. At follow-up (2003-2007), digital macular photographs were graded for early, intermediate and late AMD. Data were analysed using multinomial logistic regression controlling for age, sex, smoking, region of descent, diet and alcohol. Effect modification by sex was investigated. RESULTS: Out of 20 816 participants, early, intermediate and late AMD were detected at follow-up in 4244 (21%), 2661 (13%) and 122 (0.6%) participants, respectively. No association was detected between past total recreational physical activity and early, intermediate or late AMD. Frequent (≥3 times/week) and less frequent (1-2 times/week) vigorous exercise were associated with lower odds of intermediate and late AMD in univariable models. After controlling for confounders, there was evidence of effect modification by sex and frequent vigorous exercise was associated with a 22% decrease in the odds of intermediate AMD (95% CI 4% to 36%) in women, but no association was found for men. CONCLUSIONS: Past frequent vigorous exercise may be inversely related to the presence of intermediate AMD in women. Further studies are needed to confirm whether physical activity and exercise have a protective effect for AMD. Language eng DOI 10.1136/bjophthalmol-2015-307663 Field of Research 111399 Ophthalmology and Optometry not elsewhere classified 1103 Clinical Sciences 1113 Ophthalmology And Optometry 1117 Public Health And Health Services Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2016, BMJ Persistent URL http://hdl.handle.net/10536/DRO/DU:30086752 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 10 Oct 2016, 12:50:57 EST Tue, 11 Oct 2016, 04:12:33 EST Wed, 11 Jan 2017, 11:11:03 EST Tue, 17 Jan 2017, 05:02:29 EST Tue, 24 Jan 2017, 08:22:59 EST Tue, 24 Jan 2017, 08:25:46 EST Fri, 21 Apr 2017, 13:46:26 EST Sat, 21 Jul 2018, 02:31:03 EST Filtered Full Citation counts:   Cited 14 times in TR Web of Science Cited 14 times in Scopus Search Google Scholar Access Statistics: 78 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Wed, 11 Jan 2017, 11:11:03 EST

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