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Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins.

Nienaber, Juhsien J C, Sharma Kuinkel, Batu K, Clarke-Pearson, Michael, Lamlertthon, Supaporn, Park, Lawrence, Rude, Thomas H, Barriere, Steve, Woods, Christopher W, Chu, Vivian H, Marín, Mercedes, Bukovski, Suzana, Garcia, Patricia, Corey, G Ralph, Korman, Tony, Doco-Lecompte, Thanh, Murdoch, David R, Reller, L Barth, Fowler, Vance G and International Collaboration on Endocarditis-Microbiology Investigators, 2011, Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins., Journal of infectious diseases, vol. 204, no. 5, pp. 704-713, doi: 10.1093/infdis/jir389.

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Title Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins.
Author(s) Nienaber, Juhsien J C
Sharma Kuinkel, Batu K
Clarke-Pearson, Michael
Lamlertthon, Supaporn
Park, Lawrence
Rude, Thomas H
Barriere, Steve
Woods, Christopher W
Chu, Vivian H
Marín, Mercedes
Bukovski, Suzana
Garcia, Patricia
Corey, G Ralph
Korman, Tony
Doco-Lecompte, Thanh
Murdoch, David R
Reller, L Barth
Fowler, Vance G
International Collaboration on Endocarditis-Microbiology Investigators,
Journal name Journal of infectious diseases
Volume number 204
Issue number 5
Start page 704
End page 713
Total pages 10
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2011-09-01
ISSN 1537-6613
Keyword(s) International Collaboration on Endocarditis-Microbiology Investigators
Summary BACKGROUND: Using multinational collections of methicillin-susceptible Staphylococcus aureus (MSSA) isolates from infective endocarditis (IE) and soft tissue infections (STIs), we sought to (1) validate the finding that S. aureus in clonal complex (CC) 30 is associated with hematogenous complications and (2) test the hypothesis that specific genetic characteristics in S. aureus are associated with infection severity. METHODS: IE and STI isolates from 2 cohorts were frequency matched by geographic origin. Isolates underwent spa typing to infer CC and multiplex polymerase chain reaction for presence of virulence genes. RESULTS: 114 isolate pairs were genotyped. IE isolates were more likely to be CC30 (19.5% vs 6.2%; P = .005) and to contain 3 adhesins (clfB, cna, map/eap; P < .0001 for all) and 5 enterotoxins (tst, sea, sed, see, and sei; P ≤ .005 for all). CC30 isolates were more likely to contain cna, tst, sea, see, seg, and chp (P < .05 for all). CONCLUSIONS: MSSA IE isolates were significantly more likely to be CC30 and to possess a distinct repertoire of virulence genes than MSSA STI isolates from the same region. The genetic basis of this association requires further study.
Language eng
DOI 10.1093/infdis/jir389
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, The Author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086769

Document type: Journal Article
Collection: School of Medicine
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