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Specific IgA enhances the transcytosis and excretion of hepatitis A virus

Counihan, Natalie A. and Anderson, David A. 2016, Specific IgA enhances the transcytosis and excretion of hepatitis A virus, Scientific reports, vol. 6, Article number : 21855, pp. 1-9, doi: 10.1038/srep21855.

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Title Specific IgA enhances the transcytosis and excretion of hepatitis A virus
Author(s) Counihan, Natalie A.
Anderson, David A.
Journal name Scientific reports
Volume number 6
Season Article number : 21855
Start page 1
End page 9
Total pages 9
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2016-02-25
ISSN 2045-2322
Summary Hepatitis A virus (HAV) replicates in the liver, and is excreted from the body in feces. However, the mechanisms of HAV transport from hepatocytes to the gastrointestinal tract are poorly understood, mainly due to lack of suitable in vitro models. Here, we use a polarized hepatic cell line and in vivo models to demonstrate vectorial transport of HAV from hepatocytes into bile via the apical cell membrane. Although this transport is specific for HAV, the rate of fecal excretion in inefficient, accounting for less than 1% of input virus from the bloodstream per hour. However, we also found that the rate of HAV excretion was enhanced in the presence of HAV-specific IgA. Using mice lacking the polymeric IgA receptor (pIgR-/-), we show that a proportion of HAV:IgA complexes are transported via the pIgR demonstrating a role for specific antibody in pathogen excretion.
Language eng
DOI 10.1038/srep21855
Field of Research 110799 Immunology not elsewhere classified
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086816

Document type: Journal Article
Collections: School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.