Hydrophilic-hydrophobic polymer blend for modulation of crystalline changes and molecular interactions in solid dispersion

Van Ngo, Hai, Nguyen, Phuc Kien, Van Vo, Toi, Duan, Wei, Tran, Van-Thanh, Tran, Phuong Ha-Lien and Tran, Thao Truong-Dinh 2016, Hydrophilic-hydrophobic polymer blend for modulation of crystalline changes and molecular interactions in solid dispersion, International journal of pharmaceutics, vol. 513, no. 1-2, pp. 148-152, doi: 10.1016/j.ijpharm.2016.09.017.

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Title Hydrophilic-hydrophobic polymer blend for modulation of crystalline changes and molecular interactions in solid dispersion
Author(s) Van Ngo, Hai
Nguyen, Phuc Kien
Van Vo, Toi
Duan, WeiORCID iD for Duan, Wei orcid.org/0000-0001-5782-9184
Tran, Van-Thanh
Tran, Phuong Ha-LienORCID iD for Tran, Phuong Ha-Lien orcid.org/0000-0001-8463-7516
Tran, Thao Truong-Dinh
Journal name International journal of pharmaceutics
Volume number 513
Issue number 1-2
Start page 148
End page 152
Total pages 5
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-11-20
ISSN 0378-5173
Keyword(s) Drug crystal
Hydrophilic-hydrophobic polymer
Molecular interaction
Solid dispersion
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Summary This research study aimed to develop a new strategy for using a polymer blend in solid dispersion (SD) for dissolution enhancement of poorly water-soluble drugs. SDs with different blends of hydrophilic-hydrophobic polymers (zein/hydroxypropyl methylcellulose - zein/HPMC) were prepared using spray drying to modulate the drug crystal and polymer-drug interactions in SDs. Physicochemical characterizations, including power X-ray diffraction and Fourier transform infrared spectroscopy, were performed to elucidate the roles of the blends in SDs. Although hydrophobic polymers played a key role in changing the model drug from a crystal to an amorphous state, the dissolution rate was limited due to the wetting property. Fortunately, the hydrophilic-hydrophobic blend not only reduced the drug crystallinity but also resulted in a hydrogen bonding interaction between the drugs and the polymer for a dissolution rate improvement. This work may contribute to a new generation of solid dispersion using a blend of hydrophilic-hydrophobic polymers for an effective dissolution enhancement of poorly water-soluble drugs.
Language eng
DOI 10.1016/j.ijpharm.2016.09.017
Field of Research 111502 Clinical Pharmacology and Therapeutics
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 0 Not Applicable
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086870

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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