Relationship between resting blood pressure and laboratory-induced pain among healthy children

Haas, Kelly, Lu, Qian, Evans, Subhadra, Tsao, Jennie CI and Zeltzer, Lonnie K 2011, Relationship between resting blood pressure and laboratory-induced pain among healthy children, Gender medicine, vol. 8, no. 6, pp. 388-398, doi: 10.1016/j.genm.2011.07.002.

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Title Relationship between resting blood pressure and laboratory-induced pain among healthy children
Author(s) Haas, Kelly
Lu, Qian
Evans, SubhadraORCID iD for Evans, Subhadra
Tsao, Jennie CI
Zeltzer, Lonnie K
Journal name Gender medicine
Volume number 8
Issue number 6
Start page 388
End page 398
Total pages 11
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2011-12
ISSN 1550-8579
Keyword(s) blood pressure
gender differences
laboratory pain
Summary BACKGROUND: Adult studies have demonstrated that increased resting blood pressure (BP) levels correlate with decreased pain sensitivity. However, few studies have examined the relationship between BP and experimental pain sensitivity among children.

OBJECTIVES: This study investigated the association between resting BP levels and experimental pain tolerance, intensity, and unpleasantness in healthy children. We also explored whether these BP-pain relationships were age and gender dependent.

METHODS: Participants underwent separate 4-trial blocks of cutaneous pressure and thermal pain stimuli, and 1 trial of a cold pain stimulus in counterbalanced order.

RESULTS: A total of 235 healthy children (49.6% female; mean age 12.7 [2.9] years; age range 8-18 years) participated. The study revealed specific gender-based BP-pain relationships. Girls with higher resting systolic BP levels were found to have lower thermal intensity ratings than girls with lower resting systolic BP levels; this relationship was stronger among adolescent girls than among younger girls. Among young girls (8-11 years), those with higher resting diastolic BP (DBP) levels were found to have lower cold intensity and unpleasantness as well as lower thermal intensity ratings than did young girls with lower resting DBP levels; these DBP-pain response relationships were not seen among adolescent girls.

CONCLUSIONS: Age, rather than resting BP, was predictive of laboratory pain ratings in boys. The findings suggest that the relationship between BP and experimental pain is age and gender dependent. These aspects of cardiovascular relationships to pain in males and females need further attention to understand their clinical importance.
Language eng
DOI 10.1016/j.genm.2011.07.002
Field of Research 110399 Clinical Sciences not elsewhere classified
1103 Clinical Sciences
1102 Cardiovascular Medicine And Haematology
Socio Economic Objective 920501 Child Health
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, Elsevier HS Journals
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Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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