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Heart rate variability as a biomarker for autonomic nervous system response differences between children with chronic pain and healthy control children

Evans, Subhadra, Seidman, Laura C., Tsao, Jennie C. I., Lung, Kirsten C., Zeltzer, Lonnie K. and Naliboff, Bruce D. 2013, Heart rate variability as a biomarker for autonomic nervous system response differences between children with chronic pain and healthy control children, Journal of pain research, vol. 6, pp. 449-457, doi: 10.2147/JPR.S43849.

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Title Heart rate variability as a biomarker for autonomic nervous system response differences between children with chronic pain and healthy control children
Author(s) Evans, Subhadra
Seidman, Laura C.
Tsao, Jennie C. I.
Lung, Kirsten C.
Zeltzer, Lonnie K.
Naliboff, Bruce D.
Journal name Journal of pain research
Volume number 6
Start page 449
End page 457
Total pages 9
Publisher Dovepress
Place of publication Macclesfield, Eng.
Publication date 2013
Keyword(s) childhood pain
cold pressor
experimental pain
laboratory pain
pediatric pain
stress task
Summary Studies in adults have demonstrated a relationship between lowered heart rate variability (HRV) and poor health. However, less is known about the role of autonomic arousal in children's well-being. The aim of the current study was to examine resting HRV in children with chronic pain compared to healthy control children and, further, to examine children's HRV following a series of acute experimental pain tasks in both groups. Participants included 104 healthy control children and 48 children with chronic pain aged 8-17 years. The laboratory session involved a 5-minute baseline electrocardiogram followed by four pain induction tasks: evoked pressure, cold pressor, focal pressure, and a conditioned pain modulation task. After the tasks were complete, a 5-minute post-task electrocardiogram recording was taken. Spectral analysis was used to capture high-frequency normalized power and the ratio of low-to-high frequency band power, signifying cardiac vagal tone and sympathetic balance, respectively. Results revealed that children with chronic pain had significantly lower resting HRV (signified by low high-frequency normalized power and high ratio of low-to-high frequency band power) compared to healthy children; moreover, a significant interaction between groups and time revealed that children with chronic pain displayed a static HRV response to the pain session compared to healthy children, whose HRV was reduced concomitant with the pain session. These findings suggest that children with chronic pain may have a sustained stress response with minimal variability in response to new acute pain stressors.
Language eng
DOI 10.2147/JPR.S43849
Field of Research 111499 Paediatrics and Reproductive Medicine not elsewhere classified
1103 Clinical Sciences
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 920501 Child Health
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, Evans et al.
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30086951

Document type: Journal Article
Collections: School of Psychology
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.