In utero programming of allergic susceptibility

Grieger, Jessica A., Clifton, Vicki L., Tuck, Astrud R., Wooldridge, Amy L., Robertson, Sarah A. and Gatford, Kathryn L. 2016, In utero programming of allergic susceptibility, International archives of allergy and immunology, vol. 169, no. 2, pp. 80-92, doi: 10.1159/000443961.

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Title In utero programming of allergic susceptibility
Author(s) Grieger, Jessica A.
Clifton, Vicki L.
Tuck, Astrud R.
Wooldridge, Amy L.
Robertson, Sarah A.
Gatford, Kathryn L.
Journal name International archives of allergy and immunology
Volume number 169
Issue number 2
Start page 80
End page 92
Total pages 13
Publisher S Karger AG
Place of publication Basel, Switzerland
Publication date 2016-04
ISSN 1018-2438
Summary Background: Around 30-40% of the world's population will experience allergy, the most common and earliest-onset noncommunicable disease. With a steady rise in the incidence of allergic disease over recent decades, up to 18% of children will suffer a respiratory, food or skin allergy before their 18th birthday. There is compelling evidence that the risk of developing allergy is influenced by early life events and particularly in utero exposures.
Methods: A comprehensive literature review was undertaken which outlines prenatal risk factors and potential mechanisms underlying the development of allergy in childhood.
Results: Exposures including maternal cigarette smoking, preterm birth and Caesarean delivery are implicated in predisposing infants to the later development of allergy. In contrast, restricted growth in utero, a healthy maternal diet and a larger family size are protective, but the mechanisms here are unclear and require further investigation.
Conclusion: To ameliorate the allergy pandemic in young children, we must define prenatal mechanisms that alter the programming of the fetal immune system and also identify specific targets for antenatal interventions.
Language eng
DOI 10.1159/000443961
Field of Research 110701 Allergy
1107 Immunology
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, S. Karger AG, Basel
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Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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