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Validation of a Chinese version of the Quality of Well-Being Scale-Self-Administered (QWB-SA) in patients with epilepsy

Gao, Lan, Xia, Li, Pan, Song-Qing, Xiong, Tao and Li, Shu-Chuen 2013, Validation of a Chinese version of the Quality of Well-Being Scale-Self-Administered (QWB-SA) in patients with epilepsy, Epilepsia, vol. 54, no. 9, pp. 1647-1657, doi: 10.1111/epi.12324.

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Title Validation of a Chinese version of the Quality of Well-Being Scale-Self-Administered (QWB-SA) in patients with epilepsy
Author(s) Gao, Lan
Xia, Li
Pan, Song-Qing
Xiong, Tao
Li, Shu-Chuen
Journal name Epilepsia
Volume number 54
Issue number 9
Start page 1647
End page 1657
Total pages 11
Publisher Wiley
Place of publication Hoboken, N.J.
Publication date 2013-09
ISSN 0013-9580
1528-1167
Keyword(s) epilepsy
Quality of Well-Being Scale–Self-Administered
EQ-5D
utility
validation study
China
Summary Purpose: Generic preference-based health-related quality of life (HRQoL) instruments are increasingly used to estimate the quality-adjusted life years (QALYs) in cost-effectiveness/utility studies. However, no such tool has been used and validated in epilepsy patients in China. This study was conducted to validate a generic preference-based HRQoL instrument, namely the Quality of Well-Being Scale–Self-Administered (QWB-SA) in Chinese patients with epilepsy.

Methods:
Accepted translation procedures were followed to develop the Chinese QWB-SA. An epilepsy group (adults with established diagnosis of epilepsy) and a control group (adults without manifested cognitive problems) were recruited between July and October, 2012, from two tertiary hospitals in China. After giving informed consent, each subject completed both the QWB-SA and the EuroQol (EQ-5D) as well as providedsociodemographic data. Construct validity was examined by six (convergent) and two (discriminative) a priori hypotheses. Sensitivity was compared by ability to differentiate epilepsy-specific variable-based subgroups. Agreement between the QWB-SA and EQ-5D was assessed byintraclass correlation coefficient (ICC) and Bland-Altman plot.

Key Findings:
One hundred forty-four epilepsy patients and 323 control subjects were enrolled, respectively. The utility medians (interquartile range, IQR) for the QWBSA and EQ-5D were 0.673 (0.172), 0.848 (0.275) for epilepsy group and 0.775 (0.258), 1.000 (0.152) for control group, respectively. The difference in utilities between the two measures were significant (p < 0.0001). Construct validity was demonstrated by six a priori hypotheses. In addition, the QWB-SA was able to discriminate across different seizure frequency and antiepileptic drug (AED) treatment subgroups. Agreement between the QWB-SA and EQ-5D was demonstrated by ICC (0.725). Finally, the multiple linear regression analysis indicated that group and the EQ-VAS had influences on the utilitydifference of these two measures, whereas seizure frequency and number of AEDs were predictors of HRQoL as measured by the QWB-SA.

Significance:
The QWB-SA is a valid and sensitive HRQoL measure in Chinese patients with epilepsy. Compared to the EQ-5D, the QWB-SA showed superiority in coverage of health dimensions, sensitivity, and ceiling effects. However, future study is still needed to ascertain its responsiveness.
Language eng
DOI 10.1111/epi.12324
Field of Research 110399 Clinical Sciences not elsewhere classified
1103 Clinical Sciences
1109 Neurosciences
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, International League Against Epilepsy
Persistent URL http://hdl.handle.net/10536/DRO/DU:30087039

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