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Nanotheranostic based iron oxide (Fe₃O₄) saturated lactoferrin nanocapsules for colonic adenocarcinoma

Kamalapuram, Sishir K., Kanwar, Rupinder K. and Kanwar, Jagat R. 2016, Nanotheranostic based iron oxide (Fe₃O₄) saturated lactoferrin nanocapsules for colonic adenocarcinoma, Journal of biomedical nanotechnology, vol. 12, no. 9, pp. 1758-1773, doi: 10.1166/jbn.2016.2295.


Title Nanotheranostic based iron oxide (Fe₃O₄) saturated lactoferrin nanocapsules for colonic adenocarcinoma
Author(s) Kamalapuram, Sishir K.
Kanwar, Rupinder K.
Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R. orcid.org/0000-0003-3728-9568
Journal name Journal of biomedical nanotechnology
Volume number 12
Issue number 9
Start page 1758
End page 1773
Total pages 16
Publisher American Scientific Publishers
Place of publication Valencia, Calif.
Publication date 2016-09
ISSN 1550-7033
1550-7041
Keyword(s) Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Biomaterials
Science & Technology - Other Topics
Materials Science
Multimodal Nanomedicine
Iron Oxide
Lactoferrin
Adenocarcinoma
Nanotheranostic
Imaging
Nanocapsules
Summary Efficient early detection of cancer and its simultaneous therapy can improve the survival of cancer patients significantly. Recently there is great interest for the development of nanotheranostic systems with multimodal live real-time imaging ability. Novel multimodal multifunctional iron oxide (Fe3O4) saturated lactoferrin (FebLf) nanocapsules/nanocarriers (FebLf NCs) nanoformulation was fabricated. Anti-cancer nanotheranostic ability in human xenograft colonic adenocarcinoma model was conducted in vivo by employing near infrared flouroscence (NIRF) real time live mice imaging technology. FebLf NCs showed spherical morphology with 50 to 80 nm size with super paramagnetic property and exhibited profound in vivo anti-tumour efficacy, leading to regression of the xenograft colonic tumour growth over a 90 day trial period. NIRF real time imaging revealed selective localisation patterns of the FebLf NCs at the tumour site causing tumour growth inhibition. In turn, ex vivo NIRF imaging of mice organs showed enhanced tumoural uptake and biodistribution at the vital organs including spleen, intestine, kidney, and intestine. Low-density lipoprotein receptors (LDLRs), ferroportin, ferritin receptor based in vivo internalisation mechanisms and iron metabolism regulation were observed. Histopathological analysis revealed obsolute non-toxic nature of FebLf NCs in mice tissues. These observations summate biocompatible, multimodal anticancer activity of novel FebLf NCs for real time cancer therapeutic imaging leading to targeted colonic adenocarcinoma therapy.
Language eng
DOI 10.1166/jbn.2016.2295
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
0302 Inorganic Chemistry
0912 Materials Engineering
1007 Nanotechnology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, American Scientific Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30087415

Document type: Journal Article
Collection: School of Medicine
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