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Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study

Livingstone, Katherine M., Celis-Morales, Carlos, Hoeller, Ulrich, Lambrinou, Christina P., Moschonis, George, Macready, Anna L., Fallaize, Rosalind, Baur, Manuela, Roos, Franz F, Bendik, Igor, Grimaldi, Keith, Navas-Carretero, Santiago, San-Cristobal, Rodrigo, Weber, Peter, Drevon, Christian A., Manios, Yannis, Traczyk, Iwona, Gibney, Eileen R., Lovegrove, Julie A., Saris, Wim H., Daniel, Hannelore, Gibney, Mike, Martinez, J. Alfredo, Brennan, Lorraine, Hill, Tom R. and Mathers, John C. 2016, Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study, Molecular nutrition and food research, In Press, pp. 1-10, doi: 10.1002/mnfr.201600476.

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Title Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study
Author(s) Livingstone, Katherine M.
Celis-Morales, Carlos
Hoeller, Ulrich
Lambrinou, Christina P.
Moschonis, George
Macready, Anna L.
Fallaize, Rosalind
Baur, Manuela
Roos, Franz F
Bendik, Igor
Grimaldi, Keith
Navas-Carretero, Santiago
San-Cristobal, Rodrigo
Weber, Peter
Drevon, Christian A.
Manios, Yannis
Traczyk, Iwona
Gibney, Eileen R.
Lovegrove, Julie A.
Saris, Wim H.
Daniel, Hannelore
Gibney, Mike
Martinez, J. Alfredo
Brennan, Lorraine
Hill, Tom R.
Mathers, John C.
Journal name Molecular nutrition and food research
Season In Press
Start page 1
End page 10
Total pages 10
Publisher Wiley-VCH
Place of publication Weinheim, Germany
Publication date 2016-11-11
ISSN 1613-4125
1613-4133
Keyword(s) diet
environment-gene interaction
Food4Me
25-hydroxyvitamin D
sunlight
vitamin D receptor gene
Food4Me Study
Summary SCOPE: Little is known about diet- and environment-gene interactions on 25-hydroxyvitamin D (25(OH)D concentration. This cross-sectional study aimed to investigate (i) predictors of 25(OH)D concentration and relationships with vitamin D genotypes and (ii) whether dietary vitamin D intake and sunlight exposure modified these relationships.

METHODS AND RESULTS: Participants from the Food4Me study (n = 1312; age 18-79) were genotyped for vitamin D receptor (VDR) and vitamin D binding protein at baseline and a genetic risk score was calculated. Dried blood spot samples were assayed for 25(OH)D concentration and dietary and lifestyle information collected. Circulating 25(OH)D concentration was lower with increasing genetic risk score, lower in females than males, higher in supplement users than non-users and higher in summer than winter. Carriage of the minor VDR allele was associated with lower 25(OH)D concentration in participants with the least sunlight exposure. Vitamin D genotype did not influence the relationship between vitamin D intake and 25(OH)D concentration.

CONCLUSION: Age, sex, dietary vitamin D intake, country, sunlight exposure, season, and vitamin D genetic risk score were associated with circulating 25(OH)D concentration in a pan-European population. The relationship between VDR genotype and 25(OH)D concentration may be influenced by weekday sunlight exposure but not dietary vitamin D intake.
Notes On behalf of the Food4Me Study
Language eng
DOI 10.1002/mnfr.201600476
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
0908 Food Sciences
1111 Nutrition And Dietetics
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Wiley-VCH
Persistent URL http://hdl.handle.net/10536/DRO/DU:30087614

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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