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Protecting skeletal muscle with protein and amino acid during periods of disuse

Galvan, Elfego, Arentson-Lantz, Emily, Lamon, Severine and Paddon-Jones, Douglas 2016, Protecting skeletal muscle with protein and amino acid during periods of disuse, Nutrients, vol. 8, no. 7, Article number : 404, pp. 1-11, doi: 10.3390/nu8070404.

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Title Protecting skeletal muscle with protein and amino acid during periods of disuse
Author(s) Galvan, Elfego
Arentson-Lantz, Emily
Lamon, Severine
Paddon-Jones, Douglas
Journal name Nutrients
Volume number 8
Issue number 7
Season Article number : 404
Start page 1
End page 11
Total pages 11
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2016
ISSN 2072-6643
Keyword(s) bed rest
diet
inactivity
leucine
muscle health
muscle protein synthesis
Summary Habitual sedentary behavior increases risk of chronic disease, hospitalization and poor quality of life. Short-term bed rest or disuse accelerates the loss of muscle mass, function, and glucose tolerance. Optimizing nutritional practices and protein intake may reduce the consequences of disuse by preserving metabolic homeostasis and muscle mass and function. Most modes of physical inactivity have the potential to negatively impact the health of older adults more than their younger counterparts. Mechanistically, mammalian target of rapamycin complex 1 (mTORC1) signaling and muscle protein synthesis are negatively affected by disuse. This contributes to reduced muscle quality and is accompanied by impaired glucose regulation. Simply encouraging increased protein and/or energy consumption is a well-intentioned, but often impractical strategy to protect muscle health. Emerging evidence suggests that leucine supplemented meals may partially and temporarily protect skeletal muscle during disuse by preserving anabolism and mitigating reductions in mass, function and metabolic homeostasis.
Language eng
DOI 10.3390/nu8070404
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
1111 Nutrition And Dietetics
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30087665

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Created: Thu, 20 Oct 2016, 09:25:53 EST

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